血浆代谢物、收缩压、生活方式和中风风险:基于英国生物库的队列研究。

IF 6.3 2区 医学 Q1 CLINICAL NEUROLOGY
Canjia Zhang, Mingxiao Li, Miaomiao Yang, Jiaqi Lin, Jinyao Huang, Ying Lin, Xi Chen, Yongqiang Liang, Yuanhai Yang, Ziyuan Yu, Dongsheng Hu, Ming Zhang, Fulan Hu
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引用次数: 0

摘要

背景 估计中风风险与血浆代谢物、代谢风险评分(MRS)、MRS 与高血压或生活方式的组合以及与生活方式相关的代谢特征之间的关联。评估纳入 MRS 后中风风险预测模型的改进情况。方法 本研究共纳入了英国生物库中的 77315 名参与者。使用 Xgboost 和 LASSO-COX 回归选择代谢物并构建 MRS。弹性网回归用于构建与生活方式相关的代谢特征。多变量 Cox 回归用于估计代谢物、MRS、MRS 与高血压或生活方式的组合、生活方式相关代谢特征和中风风险之间的关联。结果 我们发现分别有 48、63、39 和 4 种代谢物与中风、缺血性中风(IS)、蛛网膜下腔出血(SAH)和脑内出血(ICH)的风险有关。高 MRS 会明显增加中风(HR= 2.65 [95%CI 2.09-3.35])、IS(HR= 2.45 [95%CI 1.89-3.17])、ICH(HR= 2.74 [95%CI 1.55-4.85])和 SAH(HR= 4.64 [95%CI 2.25-9.56])的风险。在组合分析中,与正常 SBP 和低 MRS 相比,正常/高 SBP 和高 MRS 会显著增加卒中风险(HR= 5.80 [95%CI: 2.75-12.27]/6.37 [95%CI 3.22-12.62])。与良好的生活方式和低 MRS 相比,良好/不良好的生活方式和高 MRS 也会显著增加卒中风险(HR= 2.38 [95% CI: 1.73-3.28]/3.86 [95% CI 2.63-5.67])。将 MRS 纳入 15 年中风和 IS 风险预测模型后,AUC 分别从 0.746 增加到 0.766 和从 0.771 增加到 0.811。代谢特征与是否坚持健康的生活方式相关(r = 0.414;P = 2.22e-16),与卒中风险成反比(HR= 0.80 [95% CI 0.73-0.86])。结论 各种代谢物和 MRS 与脑卒中、IS、ICH 和 SAH 风险显著相关。在 SBP 高或生活方式不健康的人群中,MRS 高的人可能面临更高的卒中风险,即使是那些 SBP 正常或生活方式健康的人也是如此。MRS 对中风风险预测模型的改善不大。与生活方式相关的代谢特征可降低 20% 的中风风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma metabolites, systolic blood pressure, lifestyle, and stroke risk: A prospective cohort study.

Background: To estimate the associations of stroke risk with plasma metabolites, metabolic risk score (MRS), the combinations of MRS with hypertension or lifestyle, and lifestyle-related metabolic signature. To assess the improvement of the stroke risk prediction model through the incorporation of MRS.

Methods: A total of 77,315 participants from the UK Biobank were included in this study. Xgboost and LASSO-Cox regression were used to select metabolites and construct MRS. Elastic net regression was utilized to construct the lifestyle-related metabolic signature. Multivariate Cox regression was used to estimate the associations between metabolites, MRS, the combinations of MRS with hypertension or lifestyle, lifestyle-related metabolic signature, and stroke risk.

Results: We identified 48, 63, 39, and 4 metabolites associated with the risk of stroke, ischemic stroke (IS), subarachnoid hemorrhage (SAH), and intracerebral hemorrhage (ICH), respectively. High MRS significantly increased the risk of stroke (HR = 2.65 (95% confidence interval (CI): 2.09-3.35)), IS (HR = 2.45 (95% CI: 1.89-3.17)), ICH (HR = 2.74 (95% CI: 1.55-4.85)), and SAH (HR = 4.64 (95% CI: 2.25-9.56)). In the combination analyses, compared with normal systolic blood pressure (SBP) and low MRS, normal/high SBP, and high MRS significantly increased stroke risk (HR = 5.80 (95% CI: 2.75-12.27)/6.37 (95% CI: 3.22-12.62)). A favorable/unfavorable lifestyle and high MRS also significantly increased stroke risk (HR = 2.38 (95% CI: 1.73-3.28)/3.86 (95% CI: 2.63-5.67)) compared with a favorable lifestyle and low MRS. Incorporating MRS into the 15-year stroke and IS risk prediction model increased the areas under the curves (AUCs) from 0.746 to 0.766 and from 0.771 to 0.811, respectively. The metabolic signature was correlated with adherence to a healthy lifestyle (r = 0.414; P = 2.22e-16) and inversely associated with stroke risk (HR = 0.80 (95% CI: 0.73-0.86)).

Conclusions: Various metabolites and MRS were significantly associated with the risk of stroke, IS, ICH, and SAH. Individuals with a high MRS may face an elevated stroke risk among populations with high SBP or unhealthy lifestyle, even those with normal SBP or healthy lifestyle. MRS provided modest improvement to the stroke risk prediction model. The lifestyle-related metabolic signature could reduce 20% stroke risk.

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来源期刊
International Journal of Stroke
International Journal of Stroke 医学-外周血管病
CiteScore
13.90
自引率
6.00%
发文量
132
审稿时长
6-12 weeks
期刊介绍: The International Journal of Stroke is a welcome addition to the international stroke journal landscape in that it concentrates on the clinical aspects of stroke with basic science contributions in areas of clinical interest. Reviews of current topics are broadly based to encompass not only recent advances of global interest but also those which may be more important in certain regions and the journal regularly features items of news interest from all parts of the world. To facilitate the international nature of the journal, our Associate Editors from Europe, Asia, North America and South America coordinate segments of the journal.
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