自噬在口腔癌中的作用:前景与挑战(综述)。

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI:10.3892/ijmm.2024.5440
Zhou Li, Yao Zhang, Jianhua Lei, Yunxia Wu
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引用次数: 0

摘要

自噬通过溶酶体途径捕获受损或功能失调的蛋白质和细胞器,以实现适当的细胞平衡。自噬具有鲜明的特点,在癌症等多种生理和病理情况下被赋予公认的功能。自噬可以阻止早期癌症的发展。在肿瘤细胞成功转化并发展到晚期阶段后,自噬介导的动态降解和循环系统将支持癌细胞生长和适应各种细胞应激反应,同时维持能量平衡。本研究综述了自噬在不同口腔癌发展背景和阶段中发挥的双重功能,现有的支持和反对自噬的论点,以及自噬如何促进口腔癌的癌变、耐药性、侵袭、转移和自我增殖等改变。特别关注了自噬在口腔癌过程中的机制和功能,并讨论了将某些常规药物或天然化合物作为新型药物应用于口腔癌自噬调节的最新发现。总之,需要进一步研究确定自噬促进和抑制的有效性和可靠性,同时最大限度地应对增加癌症抑制以改善临床疗效这一艰巨挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autophagy in oral cancer: Promises and challenges (Review).

Autophagy captures damaged or dysfunctional proteins and organelles through the lysosomal pathway to achieve proper cellular homeostasis. Autophagy possesses distinct characteristics and is given recognized functions in numerous physiological and pathological conditions, such as cancer. Early stage cancer development can be stopped by autophagy. After tumor cells have successfully undergone transformation and progressed to a late stage, the autophagy-mediated system of dynamic degradation and recycling will support cancer cell growth and adaptation to various cellular stress responses while preserving energy homeostasis. In the present study, the dual function that autophagy plays in various oral cancer development contexts and stages, the existing arguments for and against autophagy, and the ways in which autophagy contributes to oral cancer modifications, such as carcinogenesis, drug resistance, invasion, metastasis and self-proliferation, are reviewed. Special attention is paid to the mechanisms and functions of autophagy in oral cancer processes, and the most recent findings on the application of certain conventional drugs or natural compounds as novel agents that modulate autophagy in oral cancer are discussed. Overall, further research is needed to determine the validity and reliability of autophagy promotion and inhibition while maximizing the difficult challenge of increasing cancer suppression to improve clinical outcomes.

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来源期刊
International journal of molecular medicine
International journal of molecular medicine 医学-医学:研究与实验
CiteScore
12.30
自引率
0.00%
发文量
124
审稿时长
3 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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