依西卟吩氯化铵（XF-73）鼻凝胶可显著减少心脏手术患者在整个手术期间和早期恢复期的金黄色葡萄球菌鼻腔携带量：一项随机安慰剂对照 2 期研究的结果。

IF 3 4区医学 Q2 INFECTIOUS DISEASES

Infection Control and Hospital Epidemiology Pub Date : 2024-10-10 DOI:10.1017/ice.2024.122

Julie E Mangino, Michael S Firstenberg, William Rhys-Williams, James P Lees, Aaron Dane, William G Love, Jesus Gonzalez Moreno, Yuri Martina, Debra Barker

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引用次数: 0

摘要

金黄色葡萄球菌鼻腔携带者被随机（1:1）分配到 XF-73 或安慰剂鼻腔凝胶中，在心脏手术前 24 小时内给药 5 次。两次给药后，金黄色葡萄球菌负荷迅速下降（-2.2log10 CFU/mL；安慰剂-0.01log10 CFU/mL），并维持到手术后 6 天。在 XF-73 患者中，46.5% 接受了术后抗葡萄球菌抗生素治疗，而安慰剂患者的这一比例为 70%（P = 0.045）。

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Exeporfinium chloride (XF-73) nasal gel significantly reduces Staphylococcus aureus nasal carriage in cardiac surgery patients throughout surgery and the early recovery period: results from a randomized placebo-controlled Phase 2 study.

Staphylococcus aureus nasal carriers were randomized (1:1) to XF-73 or placebo nasal gel, administered 5x over ∼24hrs pre-cardiac surgery. S. aureus burden rapidly decreased after 2 doses (-2.2log₁₀ CFU/mL; placebo -0.01log₁₀ CFU/mL) and was maintained to 6 days post-surgery. Among XF-73 patients, 46.5% received post-operative anti-staphylococcal antibiotics versus 70% in placebo (P = 0.045).

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来源期刊

Infection Control and Hospital Epidemiology 医学-传染病学

CiteScore

6.40

自引率

6.70%

发文量

289

审稿时长

3-8 weeks

期刊介绍： Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. Written by infection control practitioners and epidemiologists and guided by an editorial board composed of the nation''s leaders in the field, ICHE provides a critical forum for this vital information.