Mansour Al Qurashi, Hanan Al-Najjar, Syed Sameer Aga, Hadeel Mohammad, Ahmed Mustafa, Mohammed Al Hindi, Abrar Ahmed, Mohammad Al Harbi, Mohammad Hasosah, Ashraf Alsahaf, Mona Aldabbagh, Sara Abed
{"title":"HBsAg 阳性母亲所生婴儿暴露后预防的疗效：沙特阿拉伯单中心经验。","authors":"Mansour Al Qurashi, Hanan Al-Najjar, Syed Sameer Aga, Hadeel Mohammad, Ahmed Mustafa, Mohammed Al Hindi, Abrar Ahmed, Mohammad Al Harbi, Mohammad Hasosah, Ashraf Alsahaf, Mona Aldabbagh, Sara Abed","doi":"10.1177/2333794X241290780","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objectives.</i> Post exposure prophylaxis (PEP) with the hepatitis B vaccine (HBVac) in combination with HBV immunoglobulins (HBIG) significantly minimizes the odds of vertical transmission of HBV to newborn infants. In this retrospective study, we aimed to evaluate the compliance and efficacy of PEP in a tertiary care center in Saudi Arabia. <i>Methods.</i> Infants were tested with HBV serological markers at 7 months of age to assess their PEP protection rate. <i>Results.</i> Out of 13,125 mothers who delivered in KAMC, 105 (0.8%) mothers were found to have HBsAg positive, with a prevalence of 8 per 1000 live births. All infants (n = 100) completed their PEP as per protocol before discharge from the hospital (2 days after delivery). Among infants (n = 59; 56.2%) who were tested at 7 months of age, all (100%) were found to be negative for HBV. <i>Conclusion.</i> PEP achieved 100% efficacy among infants who complied with the study protocol at 7 months of follow-up. The prevalence of hepatitis B among pregnant women was 8 per 1000 live births.</p>","PeriodicalId":12576,"journal":{"name":"Global Pediatric Health","volume":"11 ","pages":"2333794X241290780"},"PeriodicalIF":1.4000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490950/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Efficacy of Post-Exposure Prophylaxis in Infants Born to HBsAg-Positive Mothers: A Single Center Experience in Saudi Arabia.\",\"authors\":\"Mansour Al Qurashi, Hanan Al-Najjar, Syed Sameer Aga, Hadeel Mohammad, Ahmed Mustafa, Mohammed Al Hindi, Abrar Ahmed, Mohammad Al Harbi, Mohammad Hasosah, Ashraf Alsahaf, Mona Aldabbagh, Sara Abed\",\"doi\":\"10.1177/2333794X241290780\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objectives.</i> Post exposure prophylaxis (PEP) with the hepatitis B vaccine (HBVac) in combination with HBV immunoglobulins (HBIG) significantly minimizes the odds of vertical transmission of HBV to newborn infants. In this retrospective study, we aimed to evaluate the compliance and efficacy of PEP in a tertiary care center in Saudi Arabia. <i>Methods.</i> Infants were tested with HBV serological markers at 7 months of age to assess their PEP protection rate. <i>Results.</i> Out of 13,125 mothers who delivered in KAMC, 105 (0.8%) mothers were found to have HBsAg positive, with a prevalence of 8 per 1000 live births. All infants (n = 100) completed their PEP as per protocol before discharge from the hospital (2 days after delivery). Among infants (n = 59; 56.2%) who were tested at 7 months of age, all (100%) were found to be negative for HBV. <i>Conclusion.</i> PEP achieved 100% efficacy among infants who complied with the study protocol at 7 months of follow-up. The prevalence of hepatitis B among pregnant women was 8 per 1000 live births.</p>\",\"PeriodicalId\":12576,\"journal\":{\"name\":\"Global Pediatric Health\",\"volume\":\"11 \",\"pages\":\"2333794X241290780\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490950/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Global Pediatric Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/2333794X241290780\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global Pediatric Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/2333794X241290780","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}
The Efficacy of Post-Exposure Prophylaxis in Infants Born to HBsAg-Positive Mothers: A Single Center Experience in Saudi Arabia.
Objectives. Post exposure prophylaxis (PEP) with the hepatitis B vaccine (HBVac) in combination with HBV immunoglobulins (HBIG) significantly minimizes the odds of vertical transmission of HBV to newborn infants. In this retrospective study, we aimed to evaluate the compliance and efficacy of PEP in a tertiary care center in Saudi Arabia. Methods. Infants were tested with HBV serological markers at 7 months of age to assess their PEP protection rate. Results. Out of 13,125 mothers who delivered in KAMC, 105 (0.8%) mothers were found to have HBsAg positive, with a prevalence of 8 per 1000 live births. All infants (n = 100) completed their PEP as per protocol before discharge from the hospital (2 days after delivery). Among infants (n = 59; 56.2%) who were tested at 7 months of age, all (100%) were found to be negative for HBV. Conclusion. PEP achieved 100% efficacy among infants who complied with the study protocol at 7 months of follow-up. The prevalence of hepatitis B among pregnant women was 8 per 1000 live births.
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