抗淀粉样蛋白 beta 单克隆抗体治疗阿尔茨海默病的疗效和安全性系统综述。

IF 3.6 3区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Akanksha Chhabra, Siddhant Solanki, Prithvi Saravanabawan, Arun Venkiteswaran, NagaTarang Nimmathota, Nishi Manojkumar Modi
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引用次数: 0

摘要

导言阿尔茨海默病会通过脑质退化导致痴呆。本研究遵循 PRISMA 2020 指南,调查了单克隆抗体用于治疗阿尔茨海默病的情况,旨在找出能为阿尔茨海默病患者提供疗效和安全性最佳平衡的单克隆抗体:在 PubMed、Cochrane 图书馆和临床试验登记处等数据库中对随机对照试验进行了系统检索。研究质量采用 Cochrane 偏倚风险 2 工具进行评估。使用MMSE、ADAS-Cog和CDR-SB测试数据对认知功能和日常活动进行评估:根据CDR-SB的测量结果,利卡单抗在减少脑淀粉样蛋白和认知功能下降方面显示出有效性,与基线相比的变化为1.21。阿杜单抗的变化幅度为-0.39(-22%)。Bapineuzumab没有显示出明显的益处,得分为2.4(2.8)。Gantenerumab 的得分为 1.69(1.37,2.01),可减少淀粉样蛋白,尤其是在阿尔茨海默氏症早期阶段。Crenezumab效果不佳,得分为3.61分:研究结果提供了多种视角。与其他疗法相比,来卡尼单抗在减少脑淀粉样蛋白和减缓认知功能衰退方面最有希望。还需要进一步的研究,强调了AD治疗研究的必要性,以改变AD的发展轨迹并提供可靠的治疗。协议注册:www.crd.york.ac.uk/prospero 识别码为CRD42024504358。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A systematic review of the efficacy and safety of anti-amyloid beta monoclonal antibodies in treatment of Alzheimer's disease.

Introduction: Alzheimer's disease can cause dementia through brain matter degradation. This study investigates the monoclonal antibody usage for AD treatment, following PRISMA 2020 guidelines, and aims to discern the monoclonal antibody that offers the optimal balance of efficacy and safety for individuals with AD.

Methods: A systematic search was conducted across databases such as PubMed, Cochrane Library, and clinical trial registries for randomized controlled trials. The quality of studies was assessed using the Cochrane risk of bias 2 tool. Cognitive function and daily activities were evaluated using MMSE, ADAS-Cog, and CDR-SB test data.

Results: According to CDR-SB measurements, lecanemab showed effectiveness in reducing brain amyloid and cognitive decline, with a change from baseline of 1.21. Aducanumab resulted in a decrease of -0.39 (-22%). Bapineuzumab showed no significant benefit, with scores of 2.4 (2.8). Gantenerumab, scoring 1.69 (1.37, 2.01), reduces amyloid, particularly in early Alzheimer's stages. Crenezumab was ineffective, with a score of 3.61.

Conclusion: The findings provide various perspectives. Lecanemab showed the most promise in brain amyloid reduction and decelerating cognitive decline compared to the other therapies. Further research is needed, highlighting the necessity of AD therapeutic research to alter AD's trajectory and provide reliable treatment.

Protocol registration: www.crd.york.ac.uk/prospero identifier is CRD42024504358.

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来源期刊
Expert Opinion on Biological Therapy
Expert Opinion on Biological Therapy 医学-生物工程与应用微生物
CiteScore
8.60
自引率
0.00%
发文量
96
审稿时长
3-8 weeks
期刊介绍: Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.
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