儿科静脉注射未稀释左乙拉西坦的安全性和耐受性:回顾性队列研究。

IF 6.6 1区 医学 Q1 CLINICAL NEUROLOGY
Epilepsia Pub Date : 2024-10-19 DOI:10.1111/epi.18157
Ravipal Singh, David Troelstrup, Nikolai Dahl
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引用次数: 0

摘要

在实施急性癫痫发作治疗时,时间至关重要,而尽量减少药物准备过程中的操作延迟则具有潜在的后勤和实际优势。多项研究表明,静脉注射(IV)未稀释的左乙拉西坦(LEV)在成人中具有安全性和耐受性;然而,已发表的儿科数据却很有限。本研究旨在评估静脉注射未稀释左乙拉西坦在儿科的安全性和耐受性。这是一项回顾性、双中心、观察性队列研究,评估了在3年3个月的时间里,静脉注射未稀释(100毫克/毫升)左乙拉西坦对儿科患者造成的与浓度相关的药物不良事件。研究共纳入了 52 名患者的 60 次未稀释给药。中位年龄为 4 岁;58.3% 的患者年龄小于 5 岁。所有剂量均通过外周静脉注射管给药。最常见的静脉注射解剖部位和外周静脉注射规格(G)是肘前(66.6%)和 22G 导管(63.3%)。没有与药物浓度相关的不良反应记录。在儿科人群中,无论静脉注射解剖部位、静脉注射规格和给药剂量如何,静脉注射未稀释的 LEV 均未出现与药物浓度相关的不良反应。静脉注射未经稀释的LEV对儿科患者是安全和可耐受的。前瞻性儿科研究应评估静脉注射未稀释LEV的安全性和耐受性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Safety and tolerability of intravenous undiluted levetiracetam in pediatrics: A retrospective cohort study.

Time is critical in executing acute seizure treatment, and efforts to minimize operational delays with medication preparation confer potential logistical and practical advantages. Multiple studies have demonstrated the safety and tolerability of intravenous (IV) undiluted levetiracetam (LEV) in adults; however, published pediatric data are limited. This study aims to evaluate the safety and tolerability of IV undiluted LEV in pediatrics. This was a retrospective, dual-center, observational cohort study evaluating concentration-related adverse drug events with IV undiluted (100 mg/mL) LEV in pediatrics over a 3-year 3-month timespan. A total of 60 undiluted administrations in 52 patients were included in the study. The median age was 4 years; 58.3% of patients were younger than 5 years of age. All doses were administered via a peripheral IV line. The most common IV anatomic site and peripheral IV gauge (G) was the antecubital (66.6%) and 22G catheter (63.3%). There were no documented concentration-related adverse drug events. Regardless of IV anatomic site, IV gauge, and administered dose there were no documented concentration-related adverse effects with IV undiluted LEV in a pediatric population. IV undiluted LEV may be considered safe and tolerable in pediatrics. Prospective pediatric studies should assess the safety and tolerability of IV undiluted LEV.

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来源期刊
Epilepsia
Epilepsia 医学-临床神经学
CiteScore
10.90
自引率
10.70%
发文量
319
审稿时长
2-4 weeks
期刊介绍: Epilepsia is the leading, authoritative source for innovative clinical and basic science research for all aspects of epilepsy and seizures. In addition, Epilepsia publishes critical reviews, opinion pieces, and guidelines that foster understanding and aim to improve the diagnosis and treatment of people with seizures and epilepsy.
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