利用等离子体磁性纳米粒子同时进行光热治疗和核磁共振成像：数值研究。

IF 4.9 2区医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer methods and programs in biomedicine Pub Date : 2024-10-11 DOI:10.1016/j.cmpb.2024.108453

C. Rousseau , Q.L. Vuong , Y. Gossuin , B. Maes , G. Rosolen

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引用次数: 0

摘要

背景和目的：治疗学是诊断和治疗阶段的结合。在此，我们将重点放在同时使用光热疗法和磁共振成像上，采用一种对比光热剂，它能将入射光转化为热量，并影响横向弛豫时间，而横向弛豫时间是磁共振成像的一个关键参数。我们的研究考虑了金磁铁矿纳米壳平台，通过研究激光照射含有这些混合纳米粒子的溶液所引起的横向弛豫速率的变化，来衡量磁共振成像监测与光疗相关的加热的可行性：我们模拟了一个由水溶液和混合纳米壳组成的系统在连续激光照射下的情况，从而能够评估样品内横向弛豫速率的空间变化。我们使用的混合纳米壳平台由用于热声效应的金属/金壳和用于增强磁共振成像对比度的磁铁矿核组成。我们首先使用有限元法模拟纳米壳的光学特性。然后，通过数值积分计算激光照射产生的热量。最后，通过应用分析模型获得横向弛豫速率。此外，我们还对纳米壳的几何形状进行了优化，以满足磁共振成像和光疗技术的要求：结果：我们的研究结果表明，纳米壳的尺寸范围很窄，既能在人体生物窗口显示出等离子吸收峰，又能对激光照射的横向弛豫率做出很高的响应。此外，在这一纳米壳尺寸范围内，与未照射的情况相比，照射可使横向弛豫率改变多达 30%：在这项工作中，我们从数值上理解了光疗与核磁共振成像同时使用时的相互作用。这使得磁共振成像可以监测与光疗相关的加热。

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Concurrent photothermal therapy and nuclear magnetic resonance imaging with plasmonic–magnetic nanoparticles: A numerical study

Background and Objective

: Theranostics is the combination of the diagnostic and therapeutic phases. Here we focus on simultaneous use of photothermal therapy and magnetic resonance imaging, employing a contrast-photothermal agent that converts incident light into heat and affects the transverse relaxation time, a key magnetic resonance imaging parameter. Our work considers a gold–magnetite nanoshell platform to gauge the feasibility of magnetic resonance imaging monitoring of the heating associated with phototherapy, by studying the modification of the transverse relaxation rate induced by laser illumination of a solution containing these hybrid nanoparticles.

Methods:

We simulate a system composed of an aqueous solution with hybrid nanoshells under continuous laser irradiation, enabling the evaluation of spatial variations of the transverse relaxation rate within the sample. We work with the hybrid nanoshell platform comprising a metal/gold shell for thermoplasmonic effects and a magnetite core for magnetic resonance imaging contrast enhancement. The optical properties of the nanoshells are first obtained through simulations using the finite element method. Next, the heating generated by the laser illumination is calculated by numerical integration. Finally, the transverse relaxation rate is obtained through the application of an analytical model. Additionally, we conduct an optimization of the nanoshell geometry to fulfill requirements of both magnetic resonance imaging and phototherapy techniques.

Results:

Our findings demonstrate a narrow range of nanoshell sizes exhibiting both a plasmonic absorption peak in the human biological window and a high response to laser illumination of the transverse relaxation rate. Furthermore, the illumination can induce up to a 30% modification in transverse relaxation rate compared to the non-illuminated scenario in this range of nanoshell sizes.

Conclusions:

In this work we establish the numerical understanding of the interplay between phototherapy and nuclear magnetic resonance imaging when employed concurrently. This allows magnetic resonance imaging monitoring of the heating associated with phototherapy.

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来源期刊

Computer methods and programs in biomedicine 工程技术-工程：生物医学

CiteScore

12.30

自引率

6.60%

发文量

601

审稿时长

135 days

期刊介绍： To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.