染色质重复结构域 1 蛋白的研究进展：最新综述。

IF 9.2 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cellular & Molecular Biology Letters Pub Date : 2024-10-17 DOI:10.1186/s11658-024-00647-w

Xusan Xu, Xiaoxia Wang, Yu Li, Riling Chen, Houlang Wen, Yajun Wang, Guoda Ma

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引用次数: 0

摘要

肌动蛋白重复域 1（Ankyrin repeat domain 1，Ankrd1）是一种急性反应蛋白，属于肌肉肌动蛋白重复蛋白（MARP）家族。越来越多的证据表明，Ankrd1 在多种生物过程和疾病中发挥着至关重要的作用。本综述整合了目前有关 Ankrd1 在心肌和骨骼肌发育、神经发生、癌症、骨形成、血管生成、伤口愈合、纤维化、细胞凋亡、炎症和感染中的功能的知识。此外，还讨论了 Ankrd1 在心血管疾病和肌病中的综合作用，以及其作为候选预后和诊断生物标志物的潜力。未来，有必要对 Ankrd1 进行更多研究，以明确其在疾病中的作用，并评估其作为治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research progress of ankyrin repeat domain 1 protein: an updated review.

Ankyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) family. Accumulating evidence has revealed that Ankrd1 plays a crucial role in a wide range of biological processes and diseases. This review consolidates current knowledge on Ankrd1's functions in myocardium and skeletal muscle development, neurogenesis, cancer, bone formation, angiogenesis, wound healing, fibrosis, apoptosis, inflammation, and infection. The comprehensive profile of Ankrd1 in cardiovascular diseases, myopathy, and its potential as a candidate prognostic and diagnostic biomarker are also discussed. In the future, more studies of Ankrd1 are warranted to clarify its role in diseases and assess its potential as a therapeutic target.

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来源期刊

Cellular & Molecular Biology Letters 生物-生化与分子生物学

CiteScore

11.60

自引率

13.30%

发文量

101

审稿时长

3 months

期刊介绍： Cellular & Molecular Biology Letters is an international journal dedicated to the dissemination of fundamental knowledge in all areas of cellular and molecular biology, cancer cell biology, and certain aspects of biochemistry, biophysics and biotechnology.