通过心脏磁共振评估已接种疫苗和未接种疫苗的 SARS-CoV-2 感染史患者的左心室心肌细胞外体积和纤维化体积

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Paweł Gać, Wojciech Hajdusianek, Aleksandra Żórawik, Małgorzata Poręba, Rafał Poręba
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引用次数: 0

摘要

心脏磁共振(CMR)可评估心肌的组织特征。心肌细胞外体积(ECV)和纤维化体积(FV)的变化是敏感的早期病理标志物,对预后具有重要意义。本研究的目的是评估有 SARS-CoV-2 感染史的患者在 T1 映射序列中左心室心肌的 ECV 和 FV,同时考虑 COVID-19 疫苗接种情况。研究组由 97 名患者组成(52.54 ± 8.31 岁,53% 为女性,47% 为男性)。参与者分为三个亚组:A)有症状的 SARS-CoV-2 感染史的患者,未接种 COVID-19 疫苗(39 人);B)有症状的 SARS-CoV-2 感染史的患者,接种了完整的 COVID-19 疫苗(22 人);C)无 SARS-CoV-2 感染史者,构成对照亚组(C,36 人)。所有患者均接受了 1.5 T 心脏磁共振检查。与 B 和 C 亚组相比,A 亚组患者整个心肌的 ECV 值和第 2、5-6、8 和 10-11 节段的 ECV 值在统计学上显著增高。此外,与 B 和 C 亚组相比,A 亚组整个心肌的 FV 在统计学上明显更高。总之,未接种 COVID-19 疫苗且有 SARS-CoV-2 无症状感染史的患者与未接种 COVID-19 疫苗的患者和 COVID-19 患者相比,在 T1 映射序列中心肌 ECV 和 FV 值较高,而 COVID-19 患者之前已接种了全部疫苗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extracellular Volume and Fibrosis Volume of Left Ventricular Myocardium Assessed by Cardiac Magnetic Resonance in Vaccinated and Unvaccinated Patients with a History of SARS-CoV-2 Infection.

Cardiac magnetic resonance (CMR) enables the assessment of tissue characteristics of the myocardium. Changes in the extracellular volume (ECV) and fibrosis volume (FV) of the myocardium are sensitive and early pathogenetic markers and have prognostic significance. The aim of the study was to assess ECV and FV of left ventricular myocardium in T1 mapping sequence in patients with a history of SARS-CoV-2 infection, considering vaccination status against COVID-19. The study group consisted of 97 patients (52.54 ± 8.31 years, 53% women and 47% men). The participants were divided into three subgroups: A) patients with a history of symptomatic SARS-CoV-2 infection, unvaccinated against COVID-19 (n = 39), B) patients with a history of symptomatic SARS-CoV-2 infection, with a full vaccination schedule against COVID-19 (n = 22), and C) persons without a history of SARS-CoV-2 infection constituting the control subgroup (C, n = 36). All patients underwent 1.5 T cardiac magnetic resonance. In subgroup A compared to subgroups B and C, both the ECV whole myocardium and ECV segments 2, 5-6, 8, and 10-11 were statistically significantly higher. In addition, the ECV segment 16 was statistically significantly higher in subgroup A than in subgroup C. Also, the FV whole myocardium was statistically significantly higher in subgroup A in comparison to subgroups B and C. There were no significant differences in ECV and FV between subgroups B and C. In summary, unvaccinated against COVID-19 patients with a history of symptomatic SARS-CoV-2 infection have higher myocardial ECV and FV values in the T1 mapping sequence, compared to those without COVID-19 and those suffering from COVID-19, previously vaccinated with the full vaccination schedule.

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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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