远程缺血预处理对冠状动脉旁路移植术患者炎症标志物的影响

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research Pub Date : 2024-10-01 Epub Date: 2024-10-11 DOI:10.14740/cr1702

Cezar Luca, Alexandra Boieriu, Daniela Neculoiu, Diana Tint

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引用次数: 0

摘要

背景：本研究旨在探讨远程缺血预处理能否减轻冠状动脉旁路移植术（CABG）患者的炎症过程：本研究旨在探讨远程缺血预处理是否能减少冠状动脉旁路移植术（CABG）患者的炎症过程：我们对 80 名患者进行了病例对照研究，其中一半患者因严重冠状动脉疾病（CAD）接受了缺血预处理，随后接受了 CABG。我们使用酶联免疫吸附测定法（ELISA）评估了所有受试者的白细胞介素（IL）-1 和 IL-6 水平，使用化学发光免疫测定法（CLIA）评估了高敏肌钙蛋白 I（hsTnI）水平，使用比浊法评估了所有受试者的 C 反应蛋白（CRP）水平：结果：缺血预处理患者的促炎症标志物（IL-1、IL-6）显著下降，但CRP或hsTnI没有下降：本研究表明，远端缺血预处理可显著降低特定促炎症标志物（IL-1 和 IL-6）的水平，这可能暗示了全身性保护。结论：该研究表明，远程缺血预处理能明显降低特定促炎症标志物（IL-1 和 IL-6）的水平，这可能提示了全身保护作用，但它本身并没有显示出心脏保护作用，这一点从 hsTnI 水平没有出现统计学意义上的显著下降可以看出。

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The Impact of Remote Ischemic Preconditioning on Inflammation Markers in Patients Undergoing Coronary Artery Bypass Grafting.

Background: This study aimed to investigate if remote ischemic preconditioning reduces the inflammatory process on patients undergoing coronary artery bypass grafting (CABG).

Methods: We conducted a case-control study involving 80 patients, half of whom underwent ischemic preconditioning for severe coronary artery disease (CAD) and subsequently underwent CABG. We assessed interleukin (IL)-1 and IL-6 levels using the enzyme-linked immunosorbent assay (ELISA) method, high-sensitivity troponin I (hsTnI) using chemiluminescent immunoassay (CLIA), and C-reactive protein (CRP) using the turbidimetric method at three key time points: before surgery (visit 1 or V1), immediately postoperatively (visit 2 or V2), and 1 week postoperatively (visit 3 or V3) in all subjects.

Results: Ischemic preconditioned patients showed a significant decrease in proinflammatory markers (IL-1, IL-6) but not in CRP or hsTnI.

Conclusions: This study demonstrated that remote ischemic preconditioning significantly reduced the levels of specific proinflammatory markers (IL-1 and IL-6), which may suggest general systemic protection. However, it did not demonstrate cardioprotection per se, as evidenced by the absence of a statistically significant decrease in hsTnI level.

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来源期刊

Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.