麻醉深度监测在预测胃肠道肿瘤麻醉阻滞患者 POCD 方面的价值。

IF 2.3 3区 医学 Q2 ANESTHESIOLOGY
Xizhong Ma, Xueli Zhao, Ruina Guo, Zhixun Hu, Jianghong Liu, Hongfeng Nie
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引用次数: 0

摘要

研究背景本研究的目的是评估Narcotrend(NT)监测对胃肠道肿瘤麻醉阻滞患者认知功能障碍的疗效及其对脑氧代谢和炎症反应的影响:方法:将准备接受胃肠道肿瘤切除术的患者随机分为对照组(根据医生经验评估麻醉深度)和研究组(通过NT监测麻醉深度)。在术前(T0)、术后 12 小时(T1)、术后 24 小时(T2)和术后 48 小时(T3)阶段监测 HR 和 MAP。记录 MMSE 评分以评估认知功能的变化。用血气分析仪评估脑内氧合指标(CjvO2、CERO2 和 rSO2)。用 ELISA 法检测血清炎症指标(CRP、IL-1β 和 TNF-α)和神经功能指标(NSE 和 MBP):研究组在 T1 和 T2 阶段的 MAP 均高于对照组(P 2),CERO2 和 rSO2 均显著高于对照组(P 结论:NT 监测对麻醉深度的评估具有重要意义:NT 监测麻醉深度对胃肠道肿瘤麻醉阻滞患者的身体影响较小,可降低术后 POCD 的程度,具有重要的临床价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Value of narcotrend anesthesia depth monitoring in predicting POCD in gastrointestinal tumor anesthesia block patients.

Background: The purpose of this research was to evaluate the efficacy of Narcotrend (NT) monitoring on cognitive dysfunction in patients undergoing anesthesia blockade for gastrointestinal tumors and its effect on cerebral oxygen metabolism and inflammatory response.

Methods: Patients preparing to undergo resection of gastrointestinal tumor resection were included and randomly divided into a control group (depth of anesthesia assessed by physician experience) and a research group (depth of anesthesia monitored by NT). HR and MAP were monitored at the preoperatively (T0), 12 h postoperative (T1), 24 h postoperative (T2), and 48 h postoperative (T3) stages. MMSE score was recorded to assess changes in cognitive function. Intracerebral oxygenation indicators (CjvO2, CERO2, and rSO2) were assessed by a blood gas analyzer. ELISA assay was conducted to explore the serum inflammatory indexes (CRP, IL-1β, and TNF-α) and neurological function indicators (NSE and MBP).

Results: MAP was higher in the research group than in the control group at T1 and T2 (P < 0.05). MMSE scores at T1, T2, and T3 stages were higher in the research group than in the control (P < 0.05). The incidence of POCD was also lower in the research group compared with the control (P < 0.05). CjvO2, CERO2, and rSO2 were significantly higher (P < 0.05) and were positively correlated with the MMSE scores. Postoperative serum inflammatory indexes were significantly elevated in both groups, but more significantly in the control group (P < 0.05). Both neurological function indicators were usually reduced after surgery, but the reduction was more significant in the research group (P < 0.05).

Conclusion: NT monitoring of anesthetic depth has a less physical impact on patients with gastrointestinal tumor anesthetic block, reduces the degree of postoperative POCD, and has significant clinical value.

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来源期刊
BMC Anesthesiology
BMC Anesthesiology ANESTHESIOLOGY-
CiteScore
3.50
自引率
4.50%
发文量
349
审稿时长
>12 weeks
期刊介绍: BMC Anesthesiology is an open access, peer-reviewed journal that considers articles on all aspects of anesthesiology, critical care, perioperative care and pain management, including clinical and experimental research into anesthetic mechanisms, administration and efficacy, technology and monitoring, and associated economic issues.
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