预测腹部和盆腔癌症手术患者术前六分钟步行测试的参考值模型。

IF 1.1 4区 医学 Q3 ANESTHESIOLOGY
Preet Gs Makker, Cherry Koh, Michael J Solomon, Nabila Ansari, Neil Pillinger, Linda Denehy, Bernhard Riedel, Lara Edbrooke, Jess Crowe, Duminda N Wijeysundera, Brian H Cuthbertson, Daniel Steffens
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引用次数: 0

摘要

通过六分钟步行测试(6MWT)对术前功能进行评估,可以估计手术风险并有针对性地将患者分流到康复服务机构。与普通人相比,腹部和盆腔癌症患者的术前功能较差。然而,癌症患者的六分钟步行距离(6MWD)参考值尚不清楚,这限制了对该人群 6MWT 的解释。本研究旨在为接受择期手术的腹部或盆腔癌症患者术前 6MWD 建立一个解释性参考值模型。研究对象包括在国际大医院接受腹部或盆腔癌症手术的成年患者。手术前采用标准化方案对 6MWT 进行评估。收集包括年龄、性别、身高、体重和体重指数(BMI)在内的人体测量数据,并将其纳入多元线性回归分析,以建立术前 6MWD 模型。共纳入了 742 名患者。年龄、身高和体重指数与 6MWD 相关。共估算了六个回归模型,其中两个来自整个队列,两个来自男性子集,两个来自女性子集。性别中性模型最具代表性,可解释 6MWD 变异的 15%(6MWD = 761.00-3.00 * 年龄(岁)-2.86 * BMI(kg/m2)-48.09 * 性别(M1,F2))。使用人体测量变量建立的回归模型无法很好地解释 6MWD 测量值与模型之间的差异,这表明这些模型在癌症人群中没有临床应用价值。考虑其他非人体测量变量可能会改善腹部和盆腔癌症患者术前 6MWD 的回归模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reference value models for predicting preoperative six-minute walk test in patients scheduled for abdominal and pelvic cancer surgery.

Preoperative assessment of functional capacity with the six-minute walk test (6MWT) allows for estimation of surgical risk and targeted triage to prehabilitation services. Patient with abdominal and pelvic cancers have worse preoperative function compared with the general population. However, six-minute walk distance (6MWD) reference values from cancer patients are unknown, which limits the interpretation of 6MWT in this population. This study aimed to establish an explanatory reference value model for preoperative 6MWD in patients with abdominal or pelvic cancers undergoing elective surgery. Adult patients undergoing surgery for abdominal or pelvic cancers at major international hospitals were included. The 6MWT was assessed before surgery using a standardised protocol. Anthropometric data including age, sex, height, weight and body mass index (BMI) were collected and included in multiple linear regression analysis to model preoperative 6MWD. A total of 742 patients were included. Age, height and BMI were correlated with 6MWD. Six regression models were estimated, including two from the entire cohort, two from the subset of males and two from the subset of females. A sex-neutral model was the most representative, explaining 15% of the variance in 6MWD (6MWD = 761.00-3.00 * Age (years) -2.86 * BMI (kg/m2) - 48.09 * Sex (M1, F2)). The explored regression models, using anthropometric variables, poorly explained the variance between measured and modelled 6MWD, which suggests that these models have no clinical utility in the cancer population. Consideration of additional, non-anthropometric variables may improve regression modelling of preoperative 6MWD in patients in abdominal and pelvic cancers.

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来源期刊
CiteScore
2.70
自引率
13.30%
发文量
150
审稿时长
3 months
期刊介绍: Anaesthesia and Intensive Care is an international journal publishing timely, peer reviewed articles that have educational value and scientific merit for clinicians and researchers associated with anaesthesia, intensive care medicine, and pain medicine.
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