钴催化烷基碘化物和芳基格氏试剂对丙烯酸酯的三组分烷基芳基化反应

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-10-21 DOI:10.1021/acs.orglett.4c03453

Lei Xu, Fan Zhang, Yan-En Wang, Congcong Bai, Dan Xiong, Jianyou Mao

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引用次数: 0

摘要

建立了一种高区域选择性钴催化的丙烯酸酯与烷基碘化物和芳基格氏试剂的三组分烷基芳基化反应。该反应在温和的条件下，为构建底物范围广、收率高的α-芳基酯提供了另一种有效的策略。反应规模的扩大和产物的进一步转化证明了这一方案的实用性。此外，初步的机理探索表明，高效钴催化产生的烷基自由基可瞬间加入丙烯酸酯，最终得到所需的产物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cobalt-Catalyzed Three-Component Alkyl Arylation of Acrylates with Alkyl Iodides and Aryl Grignard Reagents

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Cobalt-Catalyzed Three-Component Alkyl Arylation of Acrylates with Alkyl Iodides and Aryl Grignard Reagents

A highly regioselective cobalt-catalyzed three-component alkyl arylation of acrylates with alkyl iodides and aryl Grignard reagents has been established. The reaction efficiently provides an alternative strategy for the construction of α-aryl esters with a broad substrate scope and good yields under mild conditions. The practical applicability of this protocol is shown by the scaled-up reaction and further transformations of the products. In addition, the preliminary mechanistic explorations demonstrated that the alkyl radicals generated by the efficient cobalt catalysis are instantaneously added to the acrylates to finally afford the desired products.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.