{"title":"路易斯酸控制的钯催化环丙烯化学歧化加氢氰化反应","authors":"Rongrong Yu, Song-Zhou Cai, Xianjie Fang","doi":"10.1039/d4qo01609b","DOIUrl":null,"url":null,"abstract":"Due to the multifaceted reactivities of cyclopropenes, the divergent hydrofunctionalization of these compounds has recently attracted significant attention. Herein, we present a Pd-catalyzed hydrocyanation of cyclopropenes via aluminum Lewis acid-controlled divergent chemoselectivity. In this study, the presence of aluminum Lewis acid plays an pivotal role on the reaction pathway. In the absence of aluminum Lewis acid, the reaction predominantly yields ring-opening hydrocyanation products, whereas the addition of Lewis acid directs the formation of ring-retentive products.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lewis Acid-Controlled Pd-Catalyzed Chemodivergent Hydrocyanation of Cyclopropenes\",\"authors\":\"Rongrong Yu, Song-Zhou Cai, Xianjie Fang\",\"doi\":\"10.1039/d4qo01609b\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Due to the multifaceted reactivities of cyclopropenes, the divergent hydrofunctionalization of these compounds has recently attracted significant attention. Herein, we present a Pd-catalyzed hydrocyanation of cyclopropenes via aluminum Lewis acid-controlled divergent chemoselectivity. In this study, the presence of aluminum Lewis acid plays an pivotal role on the reaction pathway. In the absence of aluminum Lewis acid, the reaction predominantly yields ring-opening hydrocyanation products, whereas the addition of Lewis acid directs the formation of ring-retentive products.\",\"PeriodicalId\":97,\"journal\":{\"name\":\"Organic Chemistry Frontiers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Chemistry Frontiers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d4qo01609b\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4qo01609b","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Lewis Acid-Controlled Pd-Catalyzed Chemodivergent Hydrocyanation of Cyclopropenes
Due to the multifaceted reactivities of cyclopropenes, the divergent hydrofunctionalization of these compounds has recently attracted significant attention. Herein, we present a Pd-catalyzed hydrocyanation of cyclopropenes via aluminum Lewis acid-controlled divergent chemoselectivity. In this study, the presence of aluminum Lewis acid plays an pivotal role on the reaction pathway. In the absence of aluminum Lewis acid, the reaction predominantly yields ring-opening hydrocyanation products, whereas the addition of Lewis acid directs the formation of ring-retentive products.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.