压力会增强遗传性压力超反应雄性大鼠的攻击性

IF 2.4 4区 心理学 Q2 BEHAVIORAL SCIENCES
Aspen M. Harter, Chris Kim, Anna Yamazaki, Luca Lee, Michelle T. Ji, Mariya Nemesh, Eva E. Redei
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引用次数: 0

摘要

本研究调查了遗传上应激反应过度的Wistar Kyoto More Immobile(WMI)和几乎同源的对照Wistar Kyoto Less Immobile(WLI)雄性动物在居民入侵者试验中的应激诱导攻击行为。在青春期对同龄入侵者进行了测试,在成年期对同龄和幼年入侵者进行了测试。在青春期和成年期,先前的急性束缚应激减少了青少年和成年 WLI 的社会互动,并减少了它们的攻击行为。然而,与对照组和WLIs相比,之前的压力会加剧成年WMI雄性动物对同龄人和少年入侵者的攻击行为。受压的 WLIs 的主干血液中睾酮和雄烯二酮水平升高,而 WMIs 则没有,这表明雄激素在 WMIs 攻击性增强中没有直接作用。攻击行为相关基因的表达与攻击行为的致病模式相符。与各自的 WLIs 相比,对照组 WMIs 的额叶皮层和受压 WMIs 的杏仁核中的甲基-CpG 结合蛋白 2 表达量较低。额叶皮层中的血管加压素受体1a和血清素转运体的表达量增加了,只有应激后的WMI雄性动物才会出现这种情况。由于对同龄和无威胁的幼年入侵者的行为相同,因此应激引起的成年 WMI 雄性对抗行为的增加并不是因为恐惧或焦虑的增强。这些结果表明,遗传应激过度反应是应激诱发男性攻击性增加的一个危险因素。此外,由于已知的攻击性相关基因表现出与攻击性行为平行的表达模式,该模型系统可以发现导致应激增强攻击性的新分子途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stress enhances aggression in male rats with genetic stress hyper-reactivity

The current study investigated stress-induced aggressive behavior in the resident-intruder test in males of the genetically stress hyper-reactive Wistar Kyoto More Immobile (WMI), and the nearly isogenic, control Wistar Kyoto Less Immobile (WLI) strains. Tests were carried out against same-age intruders during adolescence, and same-age and juvenile intruders in adulthood. In adolescence and adulthood, prior acute restraint stress decreased social interactions and decreased aggressive behaviors of adolescents and adult WLIs. However, prior stress precipitated aggression in the adult WMI males toward both same-age, and juvenile intruders compared with control WMIs and WLIs. Trunk blood levels of testosterone and androstenedione increased in stressed WLIs, but not in WMIs, suggesting no direct role of androgens in the increased aggression of WMIs. Expressions of aggression-relevant genes showed patterns commensurate with being causative in aggressive behavior. The methyl-CpG binding protein 2 was lower in the frontal cortex of control WMIs, and in the amygdala of stressed WMIs compared with their respective WLIs. Frontal cortex expression of vasopressin receptor 1a and serotonin transporter increased, solely in WMI males after stress. As behaviors were the same toward same-age and non-threatening juvenile intruders, the stress-induced increase in confrontational behavior of the adult WMI male was not because of enhanced fear or anxiety. These results suggest that genetic stress hyper-reactivity is a risk factor for stress-induced increases in aggression in males. Additionally, as known aggression-related genes showed expression patterns paralleling aggressive behavior, this model system could identify novel molecular pathways leading to stress-enhanced aggression.

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来源期刊
Genes Brain and Behavior
Genes Brain and Behavior 医学-行为科学
CiteScore
6.80
自引率
4.00%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes. Genes Brain and Behavior is pleased to offer the following features: 8 issues per year online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions A large and varied editorial board comprising of international specialists.
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