{"title":"基于益生元的阿莫西林口服制剂的胃保护功效","authors":"Shashi Supriya, Vineet Kumar Rai, Deepak Pradhan, Jitu Halder, Tushar Kanti Rajwar, Ritu Mahanty, Ivy Saha, Priyanka Dash, Chandan Dash, Saroj Kumar Rout, Jameel Al-Tamimi, Hossan Ebaid, Salim Manoharadas, Biswakanth Kar, Goutam Ghosh, Goutam Rath","doi":"10.1007/s12247-024-09875-1","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Amoxicillin's side effects are due to its propensity to disturb gut flora. Prebiotics can aid in reversing the dysbiosis caused by antibiotics by promoting the growth of various indigenous gut flora. The present investigation aims to determine the prebiotic potential of common binders (starch, gelatin, pectin, and guar gum) against <i>L. acidophilus</i>. The further objective is to explore the potential biological advantages of amoxicillin therapy when prepared with potential prebiotic excipients.</p><h3>Methods</h3><p>In the current investigation, prebiotic-based amoxicillin granules were prepared by wet granulation method with 81.5 ± 3.26% yield. To ensure their therapeutic outcomes, prepared granules were evaluated based on drug release profile, drug degradation, prebiotic potential, in vitro antimicrobial activity, antioxidant activity, anti-inflammatory activity, and anti-diarrhoeal potential.</p><h3>Results</h3><p>After 24, 36, 48 and 60 h of incubation of <i>L. acidophilus</i> in different base materials, it was found that the growth of <i>L. acidophilus</i> was more in pectin, among other binders. Formulated granules showed better intestinal stability and sustained release profile (~ 60% release in 4 h). FTIR, DSC and XRD analyses revealed minimal interaction between the drug and the selected excipients. Granules were found to have superior <i>S. aureus</i> and <i>P. aeruginosa</i> inhibition potential compared with the pure drug and starch formulations. Also, the highest antioxidant activity was observed in the Pectin granules compared to starch granules and the pure drug. IL-6, IL1β, and TNF-α levels of the pectin-treated group show better anti-inflammatory properties than starch formulations and pure drugs. The anti-diarrhoeal effect of pectin was found to be better because it supports the growth of probiotics.</p><h3>Conclusion</h3><p>In this study, pectin-based amoxicillin granules were superior in mitigating the gastric distress associated with oral amoxicillin administration. The metabolites of probiotics reduced gut pathogens, inflammation, and oxidation, suggesting that the formulated pectin-amoxicillin granules effectively provide gastroprotection.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"19 6","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gastroprotective Efficacy of Prebiotic-based Oral Formulation of Amoxicillin\",\"authors\":\"Shashi Supriya, Vineet Kumar Rai, Deepak Pradhan, Jitu Halder, Tushar Kanti Rajwar, Ritu Mahanty, Ivy Saha, Priyanka Dash, Chandan Dash, Saroj Kumar Rout, Jameel Al-Tamimi, Hossan Ebaid, Salim Manoharadas, Biswakanth Kar, Goutam Ghosh, Goutam Rath\",\"doi\":\"10.1007/s12247-024-09875-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>Amoxicillin's side effects are due to its propensity to disturb gut flora. Prebiotics can aid in reversing the dysbiosis caused by antibiotics by promoting the growth of various indigenous gut flora. The present investigation aims to determine the prebiotic potential of common binders (starch, gelatin, pectin, and guar gum) against <i>L. acidophilus</i>. The further objective is to explore the potential biological advantages of amoxicillin therapy when prepared with potential prebiotic excipients.</p><h3>Methods</h3><p>In the current investigation, prebiotic-based amoxicillin granules were prepared by wet granulation method with 81.5 ± 3.26% yield. To ensure their therapeutic outcomes, prepared granules were evaluated based on drug release profile, drug degradation, prebiotic potential, in vitro antimicrobial activity, antioxidant activity, anti-inflammatory activity, and anti-diarrhoeal potential.</p><h3>Results</h3><p>After 24, 36, 48 and 60 h of incubation of <i>L. acidophilus</i> in different base materials, it was found that the growth of <i>L. acidophilus</i> was more in pectin, among other binders. Formulated granules showed better intestinal stability and sustained release profile (~ 60% release in 4 h). FTIR, DSC and XRD analyses revealed minimal interaction between the drug and the selected excipients. Granules were found to have superior <i>S. aureus</i> and <i>P. aeruginosa</i> inhibition potential compared with the pure drug and starch formulations. Also, the highest antioxidant activity was observed in the Pectin granules compared to starch granules and the pure drug. IL-6, IL1β, and TNF-α levels of the pectin-treated group show better anti-inflammatory properties than starch formulations and pure drugs. The anti-diarrhoeal effect of pectin was found to be better because it supports the growth of probiotics.</p><h3>Conclusion</h3><p>In this study, pectin-based amoxicillin granules were superior in mitigating the gastric distress associated with oral amoxicillin administration. The metabolites of probiotics reduced gut pathogens, inflammation, and oxidation, suggesting that the formulated pectin-amoxicillin granules effectively provide gastroprotection.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":656,\"journal\":{\"name\":\"Journal of Pharmaceutical Innovation\",\"volume\":\"19 6\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-10-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Innovation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12247-024-09875-1\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Innovation","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12247-024-09875-1","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Gastroprotective Efficacy of Prebiotic-based Oral Formulation of Amoxicillin
Purpose
Amoxicillin's side effects are due to its propensity to disturb gut flora. Prebiotics can aid in reversing the dysbiosis caused by antibiotics by promoting the growth of various indigenous gut flora. The present investigation aims to determine the prebiotic potential of common binders (starch, gelatin, pectin, and guar gum) against L. acidophilus. The further objective is to explore the potential biological advantages of amoxicillin therapy when prepared with potential prebiotic excipients.
Methods
In the current investigation, prebiotic-based amoxicillin granules were prepared by wet granulation method with 81.5 ± 3.26% yield. To ensure their therapeutic outcomes, prepared granules were evaluated based on drug release profile, drug degradation, prebiotic potential, in vitro antimicrobial activity, antioxidant activity, anti-inflammatory activity, and anti-diarrhoeal potential.
Results
After 24, 36, 48 and 60 h of incubation of L. acidophilus in different base materials, it was found that the growth of L. acidophilus was more in pectin, among other binders. Formulated granules showed better intestinal stability and sustained release profile (~ 60% release in 4 h). FTIR, DSC and XRD analyses revealed minimal interaction between the drug and the selected excipients. Granules were found to have superior S. aureus and P. aeruginosa inhibition potential compared with the pure drug and starch formulations. Also, the highest antioxidant activity was observed in the Pectin granules compared to starch granules and the pure drug. IL-6, IL1β, and TNF-α levels of the pectin-treated group show better anti-inflammatory properties than starch formulations and pure drugs. The anti-diarrhoeal effect of pectin was found to be better because it supports the growth of probiotics.
Conclusion
In this study, pectin-based amoxicillin granules were superior in mitigating the gastric distress associated with oral amoxicillin administration. The metabolites of probiotics reduced gut pathogens, inflammation, and oxidation, suggesting that the formulated pectin-amoxicillin granules effectively provide gastroprotection.
期刊介绍：
The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories:
Materials science,
Product design,
Process design, optimization, automation and control,
Facilities; Information management,
Regulatory policy and strategy,
Supply chain developments ,
Education and professional development,
Journal of Pharmaceutical Innovation publishes four issues a year.
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