化疗激发转移性卵巢癌的三级淋巴结构

IF 10 1区 医学 Q1 ONCOLOGY
Jesús Bravo Melgar,Damya Laoui
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引用次数: 0

摘要

大多数卵巢癌患者对免疫疗法仍有抵抗力,这凸显了提高这些肿瘤免疫原性的必要性。最近的一项研究揭示了化疗如何在转移性卵巢癌中诱导癌细胞应激,诱导三级淋巴结构的形成,从而创造一个 "更热 "的肿瘤微环境。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemotherapy Sparks Tertiary Lymphoid Structures in Metastatic Ovarian Cancer.
Ovarian cancer remains resistant to immunotherapy in most patients, highlighting the need to make these tumors more immunogenic. A recent study unveils how chemotherapy is able to induce cancer cell stress in metastatic ovarian carcinomas, inducing the formation of tertiary lymphoid structures that create a "hotter" tumor microenvironment.
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来源期刊
Clinical Cancer Research
Clinical Cancer Research 医学-肿瘤学
CiteScore
20.10
自引率
1.70%
发文量
1207
审稿时长
2.1 months
期刊介绍: Clinical Cancer Research is a journal focusing on groundbreaking research in cancer, specifically in the areas where the laboratory and the clinic intersect. Our primary interest lies in clinical trials that investigate novel treatments, accompanied by research on pharmacology, molecular alterations, and biomarkers that can predict response or resistance to these treatments. Furthermore, we prioritize laboratory and animal studies that explore new drugs and targeted agents with the potential to advance to clinical trials. We also encourage research on targetable mechanisms of cancer development, progression, and metastasis.
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