糖尿病和抑郁症对心血管疾病和全因死亡率的个体和联合影响：基于人群的队列研究结果

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-10-12 DOI:10.1016/j.jdiacomp.2024.108878

Qiang Tu , Karice Hyun , Shuanglan Lin , Nashid Hafiz , Deborah Manandi , Qian Zhang , Xinzheng Wang , Na Zhang , Haisheng Wu , Julie Redfern

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引用次数: 0

摘要

目的评估糖尿病和抑郁症对中国中老年人群全因死亡率和心血管疾病（CVD）的个体和联合影响。参与者被分为四个比较组：单纯糖尿病组、单纯抑郁症组、两种情况都有组和两种情况都没有组。研究人员采用多变量二元逻辑回归模型比较了四个组别的全因死亡率和心血管疾病风险。结果与未患有糖尿病和抑郁症的患者相比，仅患有糖尿病、仅患有抑郁症以及同时患有糖尿病和抑郁症的患者心血管疾病的多变量调整几率比（aORs）分别为 1.245（95 % CI 1.023 至 1.515）、1.318（95 % CI 1.171 至 1.485）和 1.722（95 % CI 1.361 至 2.178）。与同时患有糖尿病和抑郁症的人相比，同时患有糖尿病和抑郁症的人患心血管疾病和全因死亡的风险更大。

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查看原文本刊更多论文

Individual and joint effects of diabetes and depression on incident cardiovascular diseases and all-cause mortality: Results from a population-based cohort study

Aims

To assess the individual and joint effects of diabetes and depression on all-cause mortality and cardiovascular disease (CVD) in the middle-aged and elderly Chinese populations.

Methods

9105 individuals without CVD from the China Health and Retirement Longitudinal Study (CHARLS) were included and followed up for 9 years. Participants were divided into four comparative groups: diabetes alone, depression alone, both conditions, and neither condition. Multivariate binary logistic regression models were performed to compare the risks of all-cause mortality and CVD among the four groups.

Results

When compared to those without diabetes and depression, the multivariate adjusted odds ratios (aORs) for CVD in individuals who had diabetes only, depression only, and both diabetes and depression were 1.245 (95 % CI 1.023 to 1.515), 1.318 (95 % CI 1.171 to 1.485) and 1.722 (95 % CI 1.361 to 2.178), respectively. The aORs for all-cause mortality were 1.366 (95 % CI 1.035–1.804) for diabetes alone, 1.082 (95 % CI 0.916–1.279) for depression alone, and 1.590 (95 % CI 1.152–2.195) for both conditions when compared with those with neither condition.

Conclusions

Individuals with both diabetes and depression had greater risk of CVD and all-cause mortality when compared to those with diabetes or depression alone, or those without either condition.

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.