跨越边界：复制叉加合物进入溶酶体进行自噬修复

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-10-17 DOI:10.1016/j.molcel.2024.09.021

Sangin Kim, Roger A. Greenberg

引用次数: 0

摘要

Lascaux 等人最近在《细胞》（Cell）杂志上发表的一项研究1 指出，TEX264 与溶酶体中由自噬驱动的核拓扑异构酶 1 分裂复合物（TOP1cc）的分解有关，改变了目前关于临床相关剂量的 TOP1 抑制剂作用机制的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Crossing the border: Replication fork adducts move to lysosomes for autophagic repair

In a recent study in Cell, Lascaux et al.¹ implicate TEX264 in the autophagy-driven resolution of nuclear topoisomerase 1 cleavage complexes (TOP1cc) in lysosomes, altering current concepts on the mechanism of action for clinically relevant doses of TOP1 inhibitors.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.