硫化氢癌细胞生存的一缕曙光

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-10-17 DOI:10.1016/j.molcel.2024.09.027

Jung Seung Nam, Maya S. Dixon, Iok In Christine Chio

引用次数: 0

摘要

硫化氢（H2S）可通过蛋白质在特定半胱氨酸残基上的翻译后过硫化作用来调节生物过程。在本期的《分子细胞》（Molecular Cell）杂志上，Zheng 等人1 发现 SAHH 酶是一种 H2S 底物，它在过硫化后会破坏同型半胱氨酸代谢，并使肺癌细胞对铁变态反应敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hydrogen sulfide: A whiff of trouble for cancer cell survival

Hydrogen sulfide (H₂S) can regulate biological processes by post-translational persulfidation of proteins at select cysteine residues. In this issue of Molecular Cell, Zheng et al.¹ identify the enzyme SAHH as an H₂S substrate, which upon persulfidation disrupts homocysteine metabolism and sensitizes lung cancer cells to ferroptosis.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.