染色质机制停滞不前--Oncohistone 基因突变破坏了异染色质记忆

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-10-17 DOI:10.1016/j.molcel.2024.09.028

Sara R. Wasserman, Nathaniel A. Hathaway

引用次数: 0

摘要

在本期杂志中，Sinha 等人1 利用细胞染色质报告实验和 CRISPR 基因编辑技术，揭示了组蛋白 H3.3K36M 同源突变通过阻止 H3K9me3 结构域过渡到稳定抑制状态，破坏了其表观遗传记忆和稳定性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Stalling out chromatin machinery—Oncohistone mutation disrupts heterochromatin memory

In this issue, Sinha et al.¹ use cellular chromatin reporter assays along with CRISPR gene editing to reveal that the histone H3.3K36M oncohistone mutation disrupts epigenetic memory and stability of H3K9me3 domains by blocking transitions into a stably repressed state.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.