遗传学为了解β细胞功能提供了新视角

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-10-17 DOI:10.1038/s42255-024-01131-7

Amélie Bonnefond, Philippe Froguel

引用次数: 0

摘要

一项针对与胰腺β细胞功能相关的八个性状的全基因组关联研究的荟萃分析以 26,000 个个体为基础，发现了映射到 44 个位点的 55 个独立关联信号。这项研究强调了β细胞功能的新效应因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Genetics brings new insight to β-cell function

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Genetics brings new insight to β-cell function

A meta-analysis of genome-wide association study for eight traits related to pancreatic β-cell function, based on 26,000 individuals, identified 55 independent association signals mapping to 44 loci. This study highlighted new effectors of β-cell function.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.