探索果糖代谢作为胰腺癌潜在治疗方法的可能性

IF 13.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Death and Differentiation Pub Date : 2024-10-15 DOI:10.1038/s41418-024-01394-3

Chengqiang Wang, Lu Wang, Qing Zhao, Jiao Ma, Yitao Li, Junliang Kuang, Xintong Yang, Huichang Bi, Aiping Lu, Kenneth C. P. Cheung, Gerry Melino, Wei Jia

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引用次数: 0

摘要

果糖摄入过多与胰腺癌的发生和发展有关。本研究旨在阐明果糖利用与胰腺癌进展之间的关系。我们的研究结果表明，胰腺癌细胞利用果糖的能力很强，除了通过果糖转运体 GLUT5 吸收外，还能通过 AKR1B1 介导的多元醇途径将葡萄糖转化为果糖。果糖代谢通过加强糖酵解和加速产生调节血管生成的关键代谢物，加剧了胰腺癌的增殖。然而，药理作用阻断果糖代谢已被证明可减缓胰腺癌的进展，与抗血管生成药物联合使用可协同增强抗肿瘤能力。总之，以果糖代谢为靶点可能被证明是治疗胰腺癌的一种前景广阔的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer

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Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer

Excessive fructose intake has been associated with the development and progression of pancreatic cancer. This study aimed to elucidate the relationship between fructose utilization and pancreatic cancer progression. Our findings revealed that pancreatic cancer cells have a high capacity to utilize fructose and are capable of converting glucose to fructose via the AKR1B1-mediated polyol pathway, in addition to uptake via the fructose transporter GLUT5. Fructose metabolism exacerbates pancreatic cancer proliferation by enhancing glycolysis and accelerating the production of key metabolites that regulate angiogenesis. However, pharmacological blockade of fructose metabolism has been shown to slow pancreatic cancer progression and synergistically enhance anti-tumor capabilities when combined with anti-angiogenic agents. Overall, targeting fructose metabolism may prove to be a promising therapeutic approach in the treatment of pancreatic cancer.

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来源期刊

Cell Death and Differentiation 生物-生化与分子生物学

CiteScore

24.70

自引率

1.60%

发文量

181

审稿时长

3 months

期刊介绍： Mission, vision and values of Cell Death & Differentiation: To devote itself to scientific excellence in the field of cell biology, molecular biology, and biochemistry of cell death and disease. To provide a unified forum for scientists and clinical researchers It is committed to the rapid publication of high quality original papers relating to these subjects, together with topical, usually solicited, reviews, meeting reports, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.