RNA 构象动力学与功能多样性之间的联系

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in structural biology Pub Date : 2024-10-15 DOI:10.1016/j.sbi.2024.102942

Yun-Tzai Lee

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引用次数: 0

摘要

RNA 的构象动力学对生物学中的功能调控至关重要。RNA 的功能与蛋白质一样多变，但却具有多种不同的结构。在这篇综述中，我们重点回顾了 RNA 构象动力学研究的最新进展，并探讨了有关 RNA 结构及其构象动力学的一些误解。我们讨论了为什么传统的结构测定方法无法描述 RNA 的构象空间。所讨论的例子说明了具有不同作用的 RNA（包括病毒 RNA、长非编码 RNA 和催化 RNA）基于结构的机制，其中一个例子重点讨论了 HIV-1 基因组中一个 RNA 结构单元的构象异质性这一有争议的领域。

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Nexus between RNA conformational dynamics and functional versatility

RNA conformational dynamics is pivotal for functional regulations in biology. RNA can function as versatile as protein but adopts multiple distinct structures. In this review, we provide a focused review of the recent advances in studies of RNA conformational dynamics and address some of the misconceptions about RNA structure and its conformational dynamics. We discuss why the traditional methods for structure determination come up short in describing RNA conformational space. The examples discussed provide illustrations of the structure-based mechanisms of RNAs with diverse roles, including viral, long noncoding, and catalytic RNAs, one of which focuses on the debated area of conformational heterogeneity of an RNA structural element in the HIV-1 genome.

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来源期刊

Current opinion in structural biology 生物-生化与分子生物学

CiteScore

12.20

自引率

2.90%

发文量

179

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Structural Biology (COSB) aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In COSB, we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. [...] The subject of Structural Biology is divided into twelve themed sections, each of which is reviewed once a year. Each issue contains two sections, and the amount of space devoted to each section is related to its importance. -Folding and Binding- Nucleic acids and their protein complexes- Macromolecular Machines- Theory and Simulation- Sequences and Topology- New constructs and expression of proteins- Membranes- Engineering and Design- Carbohydrate-protein interactions and glycosylation- Biophysical and molecular biological methods- Multi-protein assemblies in signalling- Catalysis and Regulation