应用 ANRORC 工艺定向合成 5-脲基-2-吡唑作为具有生物活性的金糖纳米粒子共配体

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2024-10-14 DOI:10.1134/S1070428024070194

A. Y. Ershov, A. A. Martynenkov, I. V. Lagoda, A. A. Batyrenko

引用次数: 0

摘要

1-苯基-4,6-二甲基嘧啶-2(1H)-酮与 4-巯基丁尿酸酰肼的相互作用以 ANRORC（亲核体添加-开环-闭环）过程进行，形成了 1-(4-巯基丁酰基)-3,5-二甲基-5-(3-苯基氨基甲酰氨基)-2-吡唑啉，收率为 60%，是一种很有希望用于制备生物医学用途的金糖纳米颗粒的 сo 配体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Application of the ANRORC Process for Directional Synthesis of 5-Ureido-2-pyrazolines as Biologically Active Co-Ligand of Gold Glyco-Nanoparticles

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Application of the ANRORC Process for Directional Synthesis of 5-Ureido-2-pyrazolines as Biologically Active Co-Ligand of Gold Glyco-Nanoparticles

Interaction of 1-phenyl-4,6-dimethylpyrimidine-2(1H)-one with 4-mercaptobuturic acid hydrazide proceeds as ANRORC (Addition of the Nucleophile–Ring Opening–Ring Closure) process and results in the formation with 60% yield of 1-(4-mercaptobutanoyl)-3,5-dimethyl-5-(3-phenylcarbamoylamino)-2-pyrazoline as promising сo-ligand for the preparation of gold glyco-nanoparticles for biomedical purposes.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.