二维柔性药用溶胶晶体的结构基础：甲醇†吲哚美辛

IF 2.6 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

CrystEngComm Pub Date : 2024-09-23 DOI:10.1039/D4CE00920G

Aritra Bhowmik, Sanjivani Bamane and Manish Kumar Mishra

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引用次数: 0

摘要

我们报告了首个可弹性弯曲和扭转的二维药用溶胶晶体--吲哚美辛甲醇。它的柔韧性得益于交错堆积和类似各向同性相互作用的结构缓冲。我们首次在弯曲晶体区域的两个弹性面上使用了拉曼光谱，揭示了弯曲过程中晶体结构中分子分布的不均匀性，验证了二维弹性晶体的机理模型。

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Structural basis for a two-dimensional flexible pharmaceutical solvate crystal: indomethacin methanol†

We report the first two-dimensionally (2D) elastically bendable and twistable pharmaceutical-solvate crystal, indomethacin methanol. Its flexibility is due to interlocked packing and a structural buffer acting like isotropic interactions. For the first time, we utilized Raman spectroscopy on the two elastic faces of a bent crystal region, revealing the inhomogeneous molecular distribution in the crystal structure during bending and validating the mechanistic model of the 2D elastic crystal.

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来源期刊

CrystEngComm 化学-化学综合

CiteScore

5.50

自引率

9.70%

发文量

747

审稿时长

1.7 months

期刊介绍： Design and understanding of solid-state and crystalline materials