Evelyn Fitzsimons, Danwen Qian, Andrei Enica, Krupa Thakkar, Marcellus Augustine, Samuel Gamble, James L. Reading, Kevin Litchfield
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引用次数: 0
摘要
肿瘤浸润 B 细胞在肿瘤发生、发展和预后中起着重要作用,但目前还缺乏一个全面的分类系统。为了填补这一空白,我们在一个大型样本群中绘制了肿瘤浸润B细胞和浆细胞的泛癌症单细胞RNA测序(scRNA-seq)图谱。我们确定了关键的 B 细胞亚群特征,揭示了不同的亚群,并强调了这些细胞在肿瘤微环境中的异质性和功能多样性。我们探讨了 B 细胞亚群与检查点抑制剂治疗反应之间的关联,发现了亚群对总体反应的特异性影响。此外,我们还研究了 B 细胞和 T 细胞的串扰,为特定的 B 细胞亚群确定了独特的配体-受体对,并进行了空间验证。这个全面的数据集是一个宝贵的资源,它提供了一个详细的图谱,加深了人们对肿瘤中 B 细胞复杂性的了解,并为研究和治疗策略开辟了新的途径。
A pan-cancer single-cell RNA-seq atlas of intratumoral B cells
Tumor-infiltrating B cells play a significant role in tumor development, progression, and prognosis, yet a comprehensive classification system is lacking. To address this gap, we present a pan-cancer single-cell RNA sequencing (scRNA-seq) atlas of tumor-infiltrating B and plasma cells across a large sample cohort. We identify key B cell subset signatures, revealing distinct subpopulations and highlighting the heterogeneity and functional diversity of these cells in the tumor microenvironment. We explore associations between B cell subsets and checkpoint inhibitor therapy responses, finding subset-specific effects on overall response. Additionally, we examine B and T cell crosstalk, identifying unique ligand-receptor pairs for specific B cell subsets, spatially validated. This comprehensive dataset serves as a valuable resource, providing a detailed atlas that enhances the understanding of B cell complexity in tumors and opens new avenues for research and therapeutic strategies.
期刊介绍:
Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows:
Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers.
Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice.
Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers.
Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies.
Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.