锆/烟酸金属有机框架的制备、表征和评估，作为催化剂用于香蒽-1,8-二酮衍生物的一锅合成以及作为抗炎剂的对接验证

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2024-09-28 DOI:10.1016/j.jorganchem.2024.123403

Asma S. Al-Wasidi

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引用次数: 0

摘要

采用高效溶热法制备了锆/烟酸金属有机框架（MOF），并通过红外光谱、扫描电镜、电离辐射X射线、X射线衍射、BET和TEM鉴定了MOF的纳米结构。所制备的 Zr-MOF 在有机合成中作为催化剂进行了评估。在无溶剂条件下，2 摩尔二聚酮和 1 摩尔芳香醛在催化量 Zr-MOF 的存在下发生一锅反应，合成了四氢呫吨-1,8-二酮衍生物。所获得的数据表明，配体 4-(3,3,6,6-四甲基-1,8-二氧代-2,3,4,5,6,7,8,9-八氢-1H-氧杂蒽-9-基)苯基苯甲酸酯（3 克）、3,3,6、6-四甲基-9-(5-甲基呋喃-2-基)-3,4,5,6,7,9-六氢-1H-氧杂蒽-1,8(2H)-二酮 (3i) 和 9-(3-(4-氯苯基)-1-苯基-1H-吡唑-4-基)-3,3,6,6-四甲基-3,4,5,6,7,9-六氢-1H-氧杂蒽-1,8(2H)-二酮 (3j) 得到了答应的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Zirconium/niacin metal-organic framework preparation, characterization and assessment as a catalyst in one-pot synthesis of xanthene-1,8-dione derivatives with docking validation as anti-inflammatory

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Zirconium/niacin metal-organic framework preparation, characterization and assessment as a catalyst in one-pot synthesis of xanthene-1,8-dione derivatives with docking validation as anti-inflammatory

The zirconium/niacin metal-organic framework (MOF) was prepared by an efficient solvothermal method and the nanostructure of MOF was identified by IR, SEM, EDX, XRD, BET and TEM. The prepared Zr-MOF was evaluated as a catalyst in organic synthesis. Tetrahydro xanthene-1,8‑dione derivatives were synthesized by a one-pot reaction between 2 mol of dimedone and 1 mole of aromatic aldehyde in the presence of the catalytic amount of Zr-MOF under solvent-free conditions. The prepared ligands were evaluated as COX-1 and COX-2 inhibitors and the data obtained explained that the ligands 4-(3,3,6,6-tetramethyl-1,8-dioxo-2,3,4,5,6,7,8,9-octahydro-1H-xanthen-9-yl)phenyl benzoate (3 g), 3,3,6,6-tetramethyl-9-(5-methylfuran-2-yl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)‑dione (3i) and 9-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)‑dione (3j) gave the promised data.

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.