IDH突变胶质瘤T2-FLAIR错配征假阳性和假阴性的临床病理学和放射学特征

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Yuying Zang , Limei Feng , Fei Zheng , Xinyao Shi , Xuzhu Chen
{"title":"IDH突变胶质瘤T2-FLAIR错配征假阳性和假阴性的临床病理学和放射学特征","authors":"Yuying Zang ,&nbsp;Limei Feng ,&nbsp;Fei Zheng ,&nbsp;Xinyao Shi ,&nbsp;Xuzhu Chen","doi":"10.1016/j.clineuro.2024.108579","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the clinicopathological and radiological characteristics associated with false-positive and false-negative results in the identification of isocitrate dehydrogenase (IDH) mutations in gliomas using the T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign.</div></div><div><h3>Methods</h3><div>In 1515 patients with cerebral gliomas, tumor location, restricted diffusion using diffusion-weighted imaging, and the T2-FLAIR mismatch sign were retrospectively analyzed using preoperative magnetic resonance imaging. Moreover, both the false-positive and false-negative results of the T2-FLAIR mismatch sign were obtained. Univariate and multivariate logistic analyses were performed to evaluate the risk factors associated with false-positive and false-negative results.</div></div><div><h3>Results</h3><div>The overall false-positive rate was 3.5 % (53/1515), and its independent risk factors were the patient’s age (adjusted odds ratio [OR], 0.977; 95 % confidence interval [CI], 0.957, 0.997; <em>P</em> = 0.027) and non-restricted diffusion (adjusted OR, 1.968; 95 % CI, 1.060, 3.652; <em>P</em> = 0.032). The overall false-negative rate was 39.7 % (602/1515); its independent risk factors were the patient’s age (adjusted OR, 1.022; 95 % CI, 1.005, 1.038; <em>P</em> = 0.008), 1p/19q co-deletion (adjusted OR, 3.334; 95 % CI, 1.913, 5.810; <em>P</em> &lt; 0.001), and telomerase reverse transcriptase promoter mutation (adjusted OR, 2.004; 95 % CI, 1.181, 3.402; <em>P</em> = 0.010). For the mismatch sign in idiopathic IDH, the area under the receiver operating characteristic curve (AUC) was 0.602. The combined AUC for the T2-FLAIR mismatch sign and risk factors was 0.871.</div></div><div><h3>Conclusions</h3><div>Clinicopathological and radiological characteristics can lead to the misinterpretation of IDH status in gliomas based on the T2-FLAIR mismatch sign. However, this can be avoided if careful attention is paid.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"246 ","pages":"Article 108579"},"PeriodicalIF":1.8000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinicopathological and radiological characteristics of false-positive and false-negative results in T2-FLAIR mismatch sign of IDH-mutated gliomas\",\"authors\":\"Yuying Zang ,&nbsp;Limei Feng ,&nbsp;Fei Zheng ,&nbsp;Xinyao Shi ,&nbsp;Xuzhu Chen\",\"doi\":\"10.1016/j.clineuro.2024.108579\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>To explore the clinicopathological and radiological characteristics associated with false-positive and false-negative results in the identification of isocitrate dehydrogenase (IDH) mutations in gliomas using the T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign.</div></div><div><h3>Methods</h3><div>In 1515 patients with cerebral gliomas, tumor location, restricted diffusion using diffusion-weighted imaging, and the T2-FLAIR mismatch sign were retrospectively analyzed using preoperative magnetic resonance imaging. Moreover, both the false-positive and false-negative results of the T2-FLAIR mismatch sign were obtained. Univariate and multivariate logistic analyses were performed to evaluate the risk factors associated with false-positive and false-negative results.</div></div><div><h3>Results</h3><div>The overall false-positive rate was 3.5 % (53/1515), and its independent risk factors were the patient’s age (adjusted odds ratio [OR], 0.977; 95 % confidence interval [CI], 0.957, 0.997; <em>P</em> = 0.027) and non-restricted diffusion (adjusted OR, 1.968; 95 % CI, 1.060, 3.652; <em>P</em> = 0.032). The overall false-negative rate was 39.7 % (602/1515); its independent risk factors were the patient’s age (adjusted OR, 1.022; 95 % CI, 1.005, 1.038; <em>P</em> = 0.008), 1p/19q co-deletion (adjusted OR, 3.334; 95 % CI, 1.913, 5.810; <em>P</em> &lt; 0.001), and telomerase reverse transcriptase promoter mutation (adjusted OR, 2.004; 95 % CI, 1.181, 3.402; <em>P</em> = 0.010). For the mismatch sign in idiopathic IDH, the area under the receiver operating characteristic curve (AUC) was 0.602. The combined AUC for the T2-FLAIR mismatch sign and risk factors was 0.871.</div></div><div><h3>Conclusions</h3><div>Clinicopathological and radiological characteristics can lead to the misinterpretation of IDH status in gliomas based on the T2-FLAIR mismatch sign. However, this can be avoided if careful attention is paid.</div></div>\",\"PeriodicalId\":10385,\"journal\":{\"name\":\"Clinical Neurology and Neurosurgery\",\"volume\":\"246 \",\"pages\":\"Article 108579\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neurology and Neurosurgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0303846724004669\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurology and Neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0303846724004669","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的 探讨利用T2-流体加权反转恢复(FLAIR)错配征在胶质瘤中识别异柠檬酸脱氢酶(IDH)突变时,与假阳性和假阴性结果相关的临床病理学和放射学特征。方法 利用术前磁共振成像对1515例脑胶质瘤患者的肿瘤位置、弥散加权成像的局限性弥散以及T2-FLAIR错配征进行回顾性分析。此外,还得出了 T2-FLAIR 错配征的假阳性和假阴性结果。结果总体假阳性率为 3.5 %(53/1515),其独立风险因素是患者的年龄(调整后比值比 [OR],0.977;95 % 置信区间 [CI],0.957,0.997;P = 0.027)和非限制性弥散(调整后比值比 [OR],1.968;95 % 置信区间 [CI],1.060,3.652;P = 0.032)。总体假阴性率为 39.7%(602/1515);其独立风险因素是患者的年龄(调整后 OR,1.022;95 % CI,1.005,1.038;P = 0.008)、1p/19q 共缺失(调整 OR,3.334;95 % CI,1.913,5.810;P <;0.001)和端粒酶逆转录酶启动子突变(调整 OR,2.004;95 % CI,1.181,3.402;P = 0.010)。对于特发性 IDH 的错配标志,接收者操作特征曲线下面积(AUC)为 0.602。结论临床病理学和放射学特征可导致根据 T2-FLAIR 错配征误判胶质瘤的 IDH 状态。但是,如果仔细观察,这种情况是可以避免的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinicopathological and radiological characteristics of false-positive and false-negative results in T2-FLAIR mismatch sign of IDH-mutated gliomas

Purpose

To explore the clinicopathological and radiological characteristics associated with false-positive and false-negative results in the identification of isocitrate dehydrogenase (IDH) mutations in gliomas using the T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign.

Methods

In 1515 patients with cerebral gliomas, tumor location, restricted diffusion using diffusion-weighted imaging, and the T2-FLAIR mismatch sign were retrospectively analyzed using preoperative magnetic resonance imaging. Moreover, both the false-positive and false-negative results of the T2-FLAIR mismatch sign were obtained. Univariate and multivariate logistic analyses were performed to evaluate the risk factors associated with false-positive and false-negative results.

Results

The overall false-positive rate was 3.5 % (53/1515), and its independent risk factors were the patient’s age (adjusted odds ratio [OR], 0.977; 95 % confidence interval [CI], 0.957, 0.997; P = 0.027) and non-restricted diffusion (adjusted OR, 1.968; 95 % CI, 1.060, 3.652; P = 0.032). The overall false-negative rate was 39.7 % (602/1515); its independent risk factors were the patient’s age (adjusted OR, 1.022; 95 % CI, 1.005, 1.038; P = 0.008), 1p/19q co-deletion (adjusted OR, 3.334; 95 % CI, 1.913, 5.810; P < 0.001), and telomerase reverse transcriptase promoter mutation (adjusted OR, 2.004; 95 % CI, 1.181, 3.402; P = 0.010). For the mismatch sign in idiopathic IDH, the area under the receiver operating characteristic curve (AUC) was 0.602. The combined AUC for the T2-FLAIR mismatch sign and risk factors was 0.871.

Conclusions

Clinicopathological and radiological characteristics can lead to the misinterpretation of IDH status in gliomas based on the T2-FLAIR mismatch sign. However, this can be avoided if careful attention is paid.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Clinical Neurology and Neurosurgery
Clinical Neurology and Neurosurgery 医学-临床神经学
CiteScore
3.70
自引率
5.30%
发文量
358
审稿时长
46 days
期刊介绍: Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信