脑瘫青少年感知运动皮层与运动练习有关的变化。

IF 4.1 Q1 CLINICAL NEUROLOGY
Brain communications Pub Date : 2024-09-26 eCollection Date: 2024-01-01 DOI:10.1093/braincomms/fcae332
Max J Kurz, Brittany K Taylor, Elizabeth Heinrichs-Graham, Rachel K Spooner, Sarah E Baker, Tony W Wilson
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引用次数: 0

摘要

脑瘫青少年的感觉运动皮层动态变化似乎与他们的运动表现失误和非典型活动能力密切相关。很少有研究将这些皮质动力学作为潜在的生物标志物,用于预测物理治疗后可能出现的运动表现变化程度,或用于设计针对青少年特定神经生理缺陷的新治疗干预措施。这项队列调查旨在评估脑瘫青少年的感觉运动皮层振荡随练习而发生的变化,以弥补这一不足。我们使用脑磁图对脑瘫青少年(人数 = 25;年龄 = 15.2 ± 4.5 岁;粗大运动功能分类得分 I-III 级)和神经正常对照组(人数 = 18;年龄 = 14.6 ± 3.1 岁)练习伸膝等距目标匹配任务前后的皮层振荡变化进行了成像。随后,研究人员利用结构方程模型评估了练习后β(16-22赫兹)和γ(66-82赫兹)振荡变化与运动表现之间的多变量关系。结构方程模型的结果表明,练习后反应时间较快的脑瘫青少年,其感知运动皮层的运动周β振荡往往也较强。据推断,较强的贝塔振荡反映了所选运动计划的确定性更高。模型还表明,那些较少越过目标且较快匹配目标的脑瘫青少年在练习后往往会在感觉运动皮层中产生较强的与执行相关的伽马反应。这种较强的伽马反应可能代表了感觉运动神经发生器的激活改善和/或GABA能神经元间抑制-兴奋动力学的改变。这些新颖的神经生理学结果为我们提供了一个窗口,让我们了解在物理治疗过程中与练习相关的潜在神经变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Motor practice related changes in the sensorimotor cortices of youth with cerebral palsy.

The altered sensorimotor cortical dynamics seen in youth with cerebral palsy appear to be tightly coupled with their motor performance errors and uncharacteristic mobility. Very few investigations have used these cortical dynamics as potential biomarkers to predict the extent of the motor performance changes that might be seen after physical therapy or in the design of new therapeutic interventions that target a youth's specific neurophysiological deficits. This cohort investigation was directed at evaluating the practice dependent changes in the sensorimotor cortical oscillations exhibited by youth with cerebral palsy as a step towards addressing this gap. We used magnetoencephalography to image the changes in the cortical oscillations before and after youth with cerebral palsy (N = 25; age = 15.2 ± 4.5 years; Gross Motor Function Classification Score Levels I-III) and neurotypical controls (N = 18; age = 14.6 ± 3.1 years) practiced a knee extension isometric target-matching task. Subsequently, structural equation modelling was used to assess the multivariate relationship between changes in beta (16-22 Hz) and gamma (66-82 Hz) oscillations and the motor performance after practice. The structural equation modelling results suggested youth with cerebral palsy who had a faster reaction time after practice tended to also have a stronger peri-movement beta oscillation in the sensorimotor cortices following practicing. The stronger beta oscillations were inferred to reflect greater certainty in the selected motor plan. The models also indicated that youth with cerebral palsy who overshot the targets less and matched the targets sooner tended to have a stronger execution-related gamma response in the sensorimotor cortices after practice. This stronger gamma response may represent improve activation of the sensorimotor neural generators and/or alterations in the GABAergic interneuron inhibitory-excitatory dynamics. These novel neurophysiological results provide a window on the potential neurological changes governing the practice-related outcomes in the context of the physical therapy.

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