Alison J. Howell MBChB , Devin Chetan MD , Alvise Guariento MD, PhD , Areeba Zubair , Claudia Almeida MD , Marisha McClean MD , Lynne E. Nield MD , Luc Mertens MD, PhD , Chun-Po Steve Fan PhD , David Barron MBBS, PhD , Osami Honjo MD, PhD
{"title":"房室隔缺损修复术后左房室瓣手术的疗效。","authors":"Alison J. Howell MBChB , Devin Chetan MD , Alvise Guariento MD, PhD , Areeba Zubair , Claudia Almeida MD , Marisha McClean MD , Lynne E. Nield MD , Luc Mertens MD, PhD , Chun-Po Steve Fan PhD , David Barron MBBS, PhD , Osami Honjo MD, PhD","doi":"10.1016/j.jtcvs.2024.09.051","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>A left atrioventricular valve (LAVV) operation following repair of an atrioventricular septal defect (AVSD) can be challenging. We sought to describe characteristics and outcomes of patients requiring LAVV operation.</div></div><div><h3>Methods</h3><div>This was a retrospective review of AVSDs requiring LAVV operation between 2000 and 2020. Patients who experienced adverse events (AEs), defined as the need for a LAVV reoperation (repair or replacement) or death, were compared to patients without AEs. Freedom from AEs was determined using the Kaplan-Meier method. Reoperation and death were characterized in terms of cumulative incidence function, estimated using competing risk models.</div></div><div><h3>Results</h3><div>Of 843 patients with an AVSD repair, 59 (7.3%) required an LAVV operation and 7 (9%) needed valve replacement. A simple repair (cleft closure and/or annuloplasty) was performed in 26 patients (48.1%) and complex repair using multiple techniques was performed in 28 patients (51.8%). Eleven patients (20%) required further LAVV reoperation, including replacement of mechanical valve in 3, new valve replacement in 6 (2 Melody, 4 mechanical) and re-repair in 2. The cumulative incidence of freedom from AE was 84.1% (95% confidence interval [CI], 75.0%-94.2%) at 1 year, 78.3% (95% CI, 68.2%-90.0%) at 5 years, 73.4% (95% CI, 62.2%-86.7%) at 10 years, and 69.7% (95% CI, 57.5%-84.7%) at 15 years. Cox univariable regression identified lighter weight (<em>P</em> = .027) and early need for LAVV operation (<em>P</em> = .02) as associated with AEs and cleft closure (<em>P</em> = .003) as protective against AEs. The estimated cumulative incidence of reoperation was higher in complex repairs (17.3% [95% CI, 7.8%-38.7%] vs 0.5% [NA] at 1 year (<em>P</em> = .02, Gray's test)). A comparison of eras—2000-2009 and 2010-2020—showed no difference in AEs (<em>P</em> = .96, Grays test).</div></div><div><h3>Conclusions</h3><div>Adverse outcomes remain common following LAVV operation. Smaller infants and infants requiring earlier operation and complex type repairs are at greatest risk. Future studies should focus on which high-risk LAVVs are more suited to early LAVV replacement.</div></div>","PeriodicalId":49975,"journal":{"name":"Journal of Thoracic and Cardiovascular Surgery","volume":"169 4","pages":"Pages 1044-1054"},"PeriodicalIF":4.9000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Outcomes of left atrioventricular valve operation following atrioventricular septal defect repair\",\"authors\":\"Alison J. Howell MBChB , Devin Chetan MD , Alvise Guariento MD, PhD , Areeba Zubair , Claudia Almeida MD , Marisha McClean MD , Lynne E. Nield MD , Luc Mertens MD, PhD , Chun-Po Steve Fan PhD , David Barron MBBS, PhD , Osami Honjo MD, PhD\",\"doi\":\"10.1016/j.jtcvs.2024.09.051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>A left atrioventricular valve (LAVV) operation following repair of an atrioventricular septal defect (AVSD) can be challenging. We sought to describe characteristics and outcomes of patients requiring LAVV operation.</div></div><div><h3>Methods</h3><div>This was a retrospective review of AVSDs requiring LAVV operation between 2000 and 2020. Patients who experienced adverse events (AEs), defined as the need for a LAVV reoperation (repair or replacement) or death, were compared to patients without AEs. Freedom from AEs was determined using the Kaplan-Meier method. Reoperation and death were characterized in terms of cumulative incidence function, estimated using competing risk models.</div></div><div><h3>Results</h3><div>Of 843 patients with an AVSD repair, 59 (7.3%) required an LAVV operation and 7 (9%) needed valve replacement. A simple repair (cleft closure and/or annuloplasty) was performed in 26 patients (48.1%) and complex repair using multiple techniques was performed in 28 patients (51.8%). Eleven patients (20%) required further LAVV reoperation, including replacement of mechanical valve in 3, new valve replacement in 6 (2 Melody, 4 mechanical) and re-repair in 2. The cumulative incidence of freedom from AE was 84.1% (95% confidence interval [CI], 75.0%-94.2%) at 1 year, 78.3% (95% CI, 68.2%-90.0%) at 5 years, 73.4% (95% CI, 62.2%-86.7%) at 10 years, and 69.7% (95% CI, 57.5%-84.7%) at 15 years. Cox univariable regression identified lighter weight (<em>P</em> = .027) and early need for LAVV operation (<em>P</em> = .02) as associated with AEs and cleft closure (<em>P</em> = .003) as protective against AEs. The estimated cumulative incidence of reoperation was higher in complex repairs (17.3% [95% CI, 7.8%-38.7%] vs 0.5% [NA] at 1 year (<em>P</em> = .02, Gray's test)). A comparison of eras—2000-2009 and 2010-2020—showed no difference in AEs (<em>P</em> = .96, Grays test).</div></div><div><h3>Conclusions</h3><div>Adverse outcomes remain common following LAVV operation. Smaller infants and infants requiring earlier operation and complex type repairs are at greatest risk. Future studies should focus on which high-risk LAVVs are more suited to early LAVV replacement.</div></div>\",\"PeriodicalId\":49975,\"journal\":{\"name\":\"Journal of Thoracic and Cardiovascular Surgery\",\"volume\":\"169 4\",\"pages\":\"Pages 1044-1054\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Thoracic and Cardiovascular Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S002252232400905X\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Thoracic and Cardiovascular Surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002252232400905X","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Outcomes of left atrioventricular valve operation following atrioventricular septal defect repair
Background
A left atrioventricular valve (LAVV) operation following repair of an atrioventricular septal defect (AVSD) can be challenging. We sought to describe characteristics and outcomes of patients requiring LAVV operation.
Methods
This was a retrospective review of AVSDs requiring LAVV operation between 2000 and 2020. Patients who experienced adverse events (AEs), defined as the need for a LAVV reoperation (repair or replacement) or death, were compared to patients without AEs. Freedom from AEs was determined using the Kaplan-Meier method. Reoperation and death were characterized in terms of cumulative incidence function, estimated using competing risk models.
Results
Of 843 patients with an AVSD repair, 59 (7.3%) required an LAVV operation and 7 (9%) needed valve replacement. A simple repair (cleft closure and/or annuloplasty) was performed in 26 patients (48.1%) and complex repair using multiple techniques was performed in 28 patients (51.8%). Eleven patients (20%) required further LAVV reoperation, including replacement of mechanical valve in 3, new valve replacement in 6 (2 Melody, 4 mechanical) and re-repair in 2. The cumulative incidence of freedom from AE was 84.1% (95% confidence interval [CI], 75.0%-94.2%) at 1 year, 78.3% (95% CI, 68.2%-90.0%) at 5 years, 73.4% (95% CI, 62.2%-86.7%) at 10 years, and 69.7% (95% CI, 57.5%-84.7%) at 15 years. Cox univariable regression identified lighter weight (P = .027) and early need for LAVV operation (P = .02) as associated with AEs and cleft closure (P = .003) as protective against AEs. The estimated cumulative incidence of reoperation was higher in complex repairs (17.3% [95% CI, 7.8%-38.7%] vs 0.5% [NA] at 1 year (P = .02, Gray's test)). A comparison of eras—2000-2009 and 2010-2020—showed no difference in AEs (P = .96, Grays test).
Conclusions
Adverse outcomes remain common following LAVV operation. Smaller infants and infants requiring earlier operation and complex type repairs are at greatest risk. Future studies should focus on which high-risk LAVVs are more suited to early LAVV replacement.
期刊介绍:
The Journal of Thoracic and Cardiovascular Surgery presents original, peer-reviewed articles on diseases of the heart, great vessels, lungs and thorax with emphasis on surgical interventions. An official publication of The American Association for Thoracic Surgery and The Western Thoracic Surgical Association, the Journal focuses on techniques and developments in acquired cardiac surgery, congenital cardiac repair, thoracic procedures, heart and lung transplantation, mechanical circulatory support and other procedures.