Takuya Osawa MD , Thibault Schaeffer MD , Mervin Schmiel MS , Michelle Bao Hoa Nguyen Cong MS , Carolin Niedermaier MS , Paul Philipp Heinisch MD, PhD , Nicole Piber MD , Stanimir Georgiev MD, PhD , Alfred Hager MD, PhD , Peter Ewert MD, PhD , Jürgen Hörer MD, PhD , Masamichi Ono MD, PhD
{"title":"主动脉-肺动脉和静脉-静脉侧支对丰坦手术后发生塑性支气管炎的影响。","authors":"Takuya Osawa MD , Thibault Schaeffer MD , Mervin Schmiel MS , Michelle Bao Hoa Nguyen Cong MS , Carolin Niedermaier MS , Paul Philipp Heinisch MD, PhD , Nicole Piber MD , Stanimir Georgiev MD, PhD , Alfred Hager MD, PhD , Peter Ewert MD, PhD , Jürgen Hörer MD, PhD , Masamichi Ono MD, PhD","doi":"10.1016/j.jtcvs.2024.09.049","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To clarify the association of the aortopulmonary collaterals (APCs)/venovenous collateral (VVCs) in patients with plastic bronchitis (PB) after the Fontan procedure.</div></div><div><h3>Methods</h3><div>All patients who underwent total cavopulmonary connection from 1994 to 2022 were reviewed. APCs/VVCs were detected using angiography. The impact of APC/VVCs, as well as other variables on the onset of plastic bronchitis, was evaluated.</div></div><div><h3>Results</h3><div>A total of 635 patients were included. Plastic bronchitis was observed in 15 (2.4%) patients, and the median duration between total cavopulmonary connection and the onset of plastic bronchitis was 1.1 years. Freedom from PB at 5 and 10 years was 97.5% and 96.5%, respectively. As for the association of PB and APCs/VVCs, patients with PB had an increased incidence of post-total cavopulmonary connection APCs (60% vs 14%, <em>P</em> < .001) and VVCs (53% vs 14%, <em>P</em> < .001). Freedom from PB was the lowest in the patients who were associated with both APCs and VVCs after total cavopulmonary connection. APCs after total cavopulmonary connection (<em>P</em> = .002; hazard ratio, 5.729), VVCs after total cavopulmonary connection (<em>P</em> = .016; hazard ratio, 3.527), and chylothorax (<em>P</em> = .019; hazard ratio, 3.662) were identified as independently associated factors with the onset of PB.</div></div><div><h3>Conclusions</h3><div>The occurrence of post-Fontan APCs and VVCs was significantly associated with the development of PB. Treatment or mitigation of collaterals may represent an opportunity to prevent the development of PB, a remaining source of post-Fontan excess morbidity and mortality.</div></div>","PeriodicalId":49975,"journal":{"name":"Journal of Thoracic and Cardiovascular Surgery","volume":"169 4","pages":"Pages 1070-1079.e3"},"PeriodicalIF":4.9000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of aortopulmonary and venovenous collaterals on the onset of plastic bronchitis after the Fontan procedure\",\"authors\":\"Takuya Osawa MD , Thibault Schaeffer MD , Mervin Schmiel MS , Michelle Bao Hoa Nguyen Cong MS , Carolin Niedermaier MS , Paul Philipp Heinisch MD, PhD , Nicole Piber MD , Stanimir Georgiev MD, PhD , Alfred Hager MD, PhD , Peter Ewert MD, PhD , Jürgen Hörer MD, PhD , Masamichi Ono MD, PhD\",\"doi\":\"10.1016/j.jtcvs.2024.09.049\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To clarify the association of the aortopulmonary collaterals (APCs)/venovenous collateral (VVCs) in patients with plastic bronchitis (PB) after the Fontan procedure.</div></div><div><h3>Methods</h3><div>All patients who underwent total cavopulmonary connection from 1994 to 2022 were reviewed. APCs/VVCs were detected using angiography. The impact of APC/VVCs, as well as other variables on the onset of plastic bronchitis, was evaluated.</div></div><div><h3>Results</h3><div>A total of 635 patients were included. Plastic bronchitis was observed in 15 (2.4%) patients, and the median duration between total cavopulmonary connection and the onset of plastic bronchitis was 1.1 years. Freedom from PB at 5 and 10 years was 97.5% and 96.5%, respectively. As for the association of PB and APCs/VVCs, patients with PB had an increased incidence of post-total cavopulmonary connection APCs (60% vs 14%, <em>P</em> < .001) and VVCs (53% vs 14%, <em>P</em> < .001). Freedom from PB was the lowest in the patients who were associated with both APCs and VVCs after total cavopulmonary connection. APCs after total cavopulmonary connection (<em>P</em> = .002; hazard ratio, 5.729), VVCs after total cavopulmonary connection (<em>P</em> = .016; hazard ratio, 3.527), and chylothorax (<em>P</em> = .019; hazard ratio, 3.662) were identified as independently associated factors with the onset of PB.</div></div><div><h3>Conclusions</h3><div>The occurrence of post-Fontan APCs and VVCs was significantly associated with the development of PB. Treatment or mitigation of collaterals may represent an opportunity to prevent the development of PB, a remaining source of post-Fontan excess morbidity and mortality.</div></div>\",\"PeriodicalId\":49975,\"journal\":{\"name\":\"Journal of Thoracic and Cardiovascular Surgery\",\"volume\":\"169 4\",\"pages\":\"Pages 1070-1079.e3\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Thoracic and Cardiovascular Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022522324009024\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Thoracic and Cardiovascular Surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022522324009024","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Impact of aortopulmonary and venovenous collaterals on the onset of plastic bronchitis after the Fontan procedure
Objective
To clarify the association of the aortopulmonary collaterals (APCs)/venovenous collateral (VVCs) in patients with plastic bronchitis (PB) after the Fontan procedure.
Methods
All patients who underwent total cavopulmonary connection from 1994 to 2022 were reviewed. APCs/VVCs were detected using angiography. The impact of APC/VVCs, as well as other variables on the onset of plastic bronchitis, was evaluated.
Results
A total of 635 patients were included. Plastic bronchitis was observed in 15 (2.4%) patients, and the median duration between total cavopulmonary connection and the onset of plastic bronchitis was 1.1 years. Freedom from PB at 5 and 10 years was 97.5% and 96.5%, respectively. As for the association of PB and APCs/VVCs, patients with PB had an increased incidence of post-total cavopulmonary connection APCs (60% vs 14%, P < .001) and VVCs (53% vs 14%, P < .001). Freedom from PB was the lowest in the patients who were associated with both APCs and VVCs after total cavopulmonary connection. APCs after total cavopulmonary connection (P = .002; hazard ratio, 5.729), VVCs after total cavopulmonary connection (P = .016; hazard ratio, 3.527), and chylothorax (P = .019; hazard ratio, 3.662) were identified as independently associated factors with the onset of PB.
Conclusions
The occurrence of post-Fontan APCs and VVCs was significantly associated with the development of PB. Treatment or mitigation of collaterals may represent an opportunity to prevent the development of PB, a remaining source of post-Fontan excess morbidity and mortality.
期刊介绍:
The Journal of Thoracic and Cardiovascular Surgery presents original, peer-reviewed articles on diseases of the heart, great vessels, lungs and thorax with emphasis on surgical interventions. An official publication of The American Association for Thoracic Surgery and The Western Thoracic Surgical Association, the Journal focuses on techniques and developments in acquired cardiac surgery, congenital cardiac repair, thoracic procedures, heart and lung transplantation, mechanical circulatory support and other procedures.