[酒精成瘾的表观遗传学变化与治疗视角]。

IF 1 Q4 PHARMACOLOGY & PHARMACY
Olivier Pierrefiche
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引用次数: 0

摘要

酒精消费是一个重大的公共健康问题。酒精使用障碍(AUD)患者可以从五种优先针对膜受体的治疗方法中获益,这些治疗方法的疗效一般都不高。然而,大量实验证据表明,表观遗传学在酒精消费的影响中扮演着重要角色,而改变表观基因组的表观药物为目前的治疗方案提供了一个有趣的替代选择。本文回顾了在不同年龄的动物模型中获得的最引人注目的实验证据,然后将其与在人类中获得的数据进行比较,并就使用表观药物的相关性得出结论。最后,文章在迷幻药、最新的相关分子和酒精摄入中的表观遗传因素之间提出了一种新的治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Epigenetic changes in alcohol addiction and therapeutic perspectives].

Alcohol consumption is a major public health issue. Patients with Alcohol Use Disorder (AUD) can benefit from five treatments that preferentially target membrane receptors, and whose efficacy is generally modest. However, a large body of experimental evidence points to an important role for epigenetics in the effects of alcohol consumption, and epidrugs that modify the epigenome offer an interesting alternative to current therapeutic options. This article reviews the most striking experimental evidence obtained at different ages in animal models, before comparing it with data obtained in humans and concluding on the relevance of using epidrugs. Finally, a new therapeutic option is suggested between psychedelics, recent molecules of interest, and epigenetic factors in alcohol intake.

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来源期刊
Annales pharmaceutiques francaises
Annales pharmaceutiques francaises PHARMACOLOGY & PHARMACY-
CiteScore
1.70
自引率
7.70%
发文量
98
期刊介绍: This journal proposes a scientific information validated and indexed to be informed about the last research works in all the domains interesting the pharmacy. The original works, general reviews, the focusing, the brief notes, subjected by the best academics and the professionals, propose a synthetic approach of the last progress accomplished in the concerned sectors. The thematic Sessions and the – life of the Academy – resume the communications which, presented in front of the national Academy of pharmacy, are in the heart of the current events.
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