应用光热显微镜研究恶性黑色素瘤皮肤病变的形成过程

IF 2.9 2区化学 Q3 CHEMISTRY, PHYSICAL

The Journal of Physical Chemistry B Pub Date : 2024-10-17 Epub Date: 2024-10-08 DOI:10.1021/acs.jpcb.4c05785

K Nakata, K Okumura, T Kobayashi

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引用次数: 0

摘要

在这项研究中，我们应用光热显微镜研究了恶性黑色素瘤的形成过程。我们使用灰度级共现矩阵（GLCM）方法分析了小鼠皮肤制备上的良性乳头状瘤、其转移癌和转移性黑色素瘤。在分析所研究的九个 GLCM 参数的基础上，研究阐明了退化和转移过程中的特征。变性前、变性中和变性后三个过程对应的特征参数的确定表明，这项研究能够检测恶性转化和相关过程。

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Application of a Photothermal Microscope To Study the Process of Cutaneous Lesion Formation of Malignant Melanoma.

In this study, we applied a photothermal microscope to study the process of malignant melanoma formation. We analyzed benign papilloma tumors, their metastatic carcinomas, and metastatic melanoma on the preparation of mouse skin using a gray-level co-occurrence matrix (GLCM) method. Based on the analysis of nine GLCM parameters investigated, the characteristics during the degenerative and metastatic processes are clarified by the investigation. The determination of characteristic parameters corresponding to three processes before, during, and after the degeneration indicated that this investigation enables the detection of the malignant transformation and related processes.

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来源期刊

The Journal of Physical Chemistry B 化学-物理化学

CiteScore

5.80

自引率

9.10%

发文量

965

审稿时长

1.6 months

期刊介绍： An essential criterion for acceptance of research articles in the journal is that they provide new physical insight. Please refer to the New Physical Insights virtual issue on what constitutes new physical insight. Manuscripts that are essentially reporting data or applications of data are, in general, not suitable for publication in JPC B.