Electrochemically driven metal-free synthesis of benzylic thioethers via C–S cross-coupling†

Organic sulfides play a crucial role in drug discovery and organic synthesis. The construction of C–S bonds usually requires strong basic conditions, transition metal catalysis, or stoichiometric oxidizing/reducing agents. Herein, we report an electrochemically driven C–S radical–radical cross coupling for the synthesis of benzylic thioethers. This approach is applicable to various benzyl halides and disulfides, providing corresponding benzylic thioethers in moderate to excellent yields. The reaction can be conducted at room temperature in air without the need for transition metals, external reducing agents, or sacrificial anodes, making it an environmentally friendly, cost-effective, and mild synthetic strategy.