芬纳和马歇尔估算肌瘤病毒毒力的方法存在问题，延迟了对兔病毒共同进化的更深入了解

IF 0.2 4区哲学 Q4 HISTORY & PHILOSOPHY OF SCIENCE

Historical Records of Australian Science Pub Date : 2024-10-04 DOI:10.1071/hr24010

Brian Cooke

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引用次数: 0

摘要

当 myxoma 病毒首次在澳大利亚释放时，人们不仅将其视为控制兔子的一种手段，而且还将其视为了解一种疾病在新宿主体内进化的一个机会。病毒很快减弱为毒性较低的变种，与此同时，兔子也产生了遗传性抗病能力。然而，与其说兔子的抗药性迅速超过了病毒的毒性，不如说肌瘤病毒已经适应并跟上了兔子抗药性增强的步伐，提高了毒性和其他保持高度传播性所必需的属性。本章不仅有益于对有害家兔的生物防治，还详细介绍了 myxomatosis 的进化过程，同时记录了在就 myxoma 病毒毒力和家兔抗药性的共同进化达成共识方面的延迟。

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Problems with Fenner and Marshall’s method of estimating myxoma virus virulence delayed a closer understanding of rabbit-virus coevolution

When myxoma virus was first released in Australia it was seen not only as a means of controlling rabbits but also an opportunity to understand the evolution of a disease in a new host. The virus quickly attenuated into less virulent variants while simultaneously rabbits built heritable resistance to the disease. Nonetheless, rather than rabbits quickly outstripping virus virulence, myxoma viruses have adapted and kept pace with increases in rabbit resistance by increasing in virulence and other attributes necessary for remaining highly transmissible. As well as benefitting the biological control of pest rabbits, this previously unrevealed chapter details the evolution of myxomatosis while also documenting the delays in reaching a consensus on the coevolution of myxoma virus virulence and rabbit resistance.

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来源期刊

Historical Records of Australian Science HISTORY & PHILOSOPHY OF SCIENCE-

CiteScore

0.90

自引率

66.70%

发文量

期刊介绍： Historical Records of Australian Science is a bi-annual journal that publishes two kinds of unsolicited manuscripts relating to the history of science, pure and applied, in Australia, New Zealand and the southwest Pacific. Historical Articles–original scholarly pieces of peer-reviewed research Historical Documents–either hitherto unpublished or obscurely published primary sources, along with a peer-reviewed scholarly introduction. The first issue of the journal (under the title Records of the Australian Academy of Science), appeared in 1966, and the current name was adopted in 1980.