Rafaela Cavalheiro do Espírito Santo PhD , Leonardo Peterson dos Santos MD , Geiziane Melo PhD , Viney Prakash Dubey PhD , Alona Rauckiene-Michaelsson PhD , Cesar Agostinis-Sobrinho PhD
{"title":"免疫性风湿病与健康成人的肌肉力量比较:一项 Meta 分析。","authors":"Rafaela Cavalheiro do Espírito Santo PhD , Leonardo Peterson dos Santos MD , Geiziane Melo PhD , Viney Prakash Dubey PhD , Alona Rauckiene-Michaelsson PhD , Cesar Agostinis-Sobrinho PhD","doi":"10.1016/j.jamda.2024.105293","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Patients with immune-mediated rheumatic diseases (IMRDs) often exhibit reduced muscle strength. Therefore, this review aimed to evaluate muscle strength in patients with IMRDs compared with healthy control and to summarize the relationship between low muscle strength and clinical features in patients with IMRDs.</div></div><div><h3>Design</h3><div>Systematic review with meta-analysis of case-control studies.</div></div><div><h3>Setting and Participants</h3><div>Patients with IMRDs.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in the Embase, MEDLINE, Web of Science, and Cochrane databases to identify relevant studies published up to November 2023 on rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and spondyloarthritis. Meta-analysis was performed using a random-effects model to determine the mean difference (MD) in muscle strength between patients with IMRDs and an age- and sex-matched healthy control group.</div></div><div><h3>Results</h3><div>We identified 11,692 studies, and 760 studies were selected for screening. Ultimately, 26 studies met the inclusion criteria, composed of 2661 individuals, mostly women. The IMRDs women group had lower handgrip muscle strength (MD, −9.53; 95% CI, −11.78 to −7.28 kg) than the healthy control group, whereas the handgrip strength men groups did not differ significantly from that of the healthy control group. Similar trend was observed in lower limb muscle strength for the IMRDs women group than the healthy control group (MD, −63.10; 95% CI, −94.18 to −32.01 Nm). Four studies examined muscle strength and clinical features in rheumatoid arthritis: one associated it with age and disease activity, 2 associated it with disease duration, and 3 associated it with physical function. In systemic lupus erythematosus, only 2 studies associated low muscle strength with age, disease activity, and fatigue. No associations were found in spondyloarthritis, and none were found in systemic sclerosis.</div></div><div><h3>Conclusions and Implications</h3><div>Patients with IMRD exhibit lower muscle strength than healthy counterparts, with low strength moderately associated with longer disease duration, worsening disease activity, and decline in physical function. Targeted interventions are crucial for preventing and managing muscle weakness in IMRDs.</div></div>","PeriodicalId":17180,"journal":{"name":"Journal of the American Medical Directors Association","volume":"25 12","pages":"Article 105293"},"PeriodicalIF":4.2000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Muscle Strength Comparison in Immune-Mediated Rheumatic Disease vs Healthy Adults: A Meta-Analysis\",\"authors\":\"Rafaela Cavalheiro do Espírito Santo PhD , Leonardo Peterson dos Santos MD , Geiziane Melo PhD , Viney Prakash Dubey PhD , Alona Rauckiene-Michaelsson PhD , Cesar Agostinis-Sobrinho PhD\",\"doi\":\"10.1016/j.jamda.2024.105293\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Patients with immune-mediated rheumatic diseases (IMRDs) often exhibit reduced muscle strength. Therefore, this review aimed to evaluate muscle strength in patients with IMRDs compared with healthy control and to summarize the relationship between low muscle strength and clinical features in patients with IMRDs.</div></div><div><h3>Design</h3><div>Systematic review with meta-analysis of case-control studies.</div></div><div><h3>Setting and Participants</h3><div>Patients with IMRDs.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in the Embase, MEDLINE, Web of Science, and Cochrane databases to identify relevant studies published up to November 2023 on rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and spondyloarthritis. Meta-analysis was performed using a random-effects model to determine the mean difference (MD) in muscle strength between patients with IMRDs and an age- and sex-matched healthy control group.</div></div><div><h3>Results</h3><div>We identified 11,692 studies, and 760 studies were selected for screening. Ultimately, 26 studies met the inclusion criteria, composed of 2661 individuals, mostly women. The IMRDs women group had lower handgrip muscle strength (MD, −9.53; 95% CI, −11.78 to −7.28 kg) than the healthy control group, whereas the handgrip strength men groups did not differ significantly from that of the healthy control group. Similar trend was observed in lower limb muscle strength for the IMRDs women group than the healthy control group (MD, −63.10; 95% CI, −94.18 to −32.01 Nm). Four studies examined muscle strength and clinical features in rheumatoid arthritis: one associated it with age and disease activity, 2 associated it with disease duration, and 3 associated it with physical function. In systemic lupus erythematosus, only 2 studies associated low muscle strength with age, disease activity, and fatigue. No associations were found in spondyloarthritis, and none were found in systemic sclerosis.</div></div><div><h3>Conclusions and Implications</h3><div>Patients with IMRD exhibit lower muscle strength than healthy counterparts, with low strength moderately associated with longer disease duration, worsening disease activity, and decline in physical function. 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Muscle Strength Comparison in Immune-Mediated Rheumatic Disease vs Healthy Adults: A Meta-Analysis
Objectives
Patients with immune-mediated rheumatic diseases (IMRDs) often exhibit reduced muscle strength. Therefore, this review aimed to evaluate muscle strength in patients with IMRDs compared with healthy control and to summarize the relationship between low muscle strength and clinical features in patients with IMRDs.
Design
Systematic review with meta-analysis of case-control studies.
Setting and Participants
Patients with IMRDs.
Methods
A comprehensive search was conducted in the Embase, MEDLINE, Web of Science, and Cochrane databases to identify relevant studies published up to November 2023 on rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and spondyloarthritis. Meta-analysis was performed using a random-effects model to determine the mean difference (MD) in muscle strength between patients with IMRDs and an age- and sex-matched healthy control group.
Results
We identified 11,692 studies, and 760 studies were selected for screening. Ultimately, 26 studies met the inclusion criteria, composed of 2661 individuals, mostly women. The IMRDs women group had lower handgrip muscle strength (MD, −9.53; 95% CI, −11.78 to −7.28 kg) than the healthy control group, whereas the handgrip strength men groups did not differ significantly from that of the healthy control group. Similar trend was observed in lower limb muscle strength for the IMRDs women group than the healthy control group (MD, −63.10; 95% CI, −94.18 to −32.01 Nm). Four studies examined muscle strength and clinical features in rheumatoid arthritis: one associated it with age and disease activity, 2 associated it with disease duration, and 3 associated it with physical function. In systemic lupus erythematosus, only 2 studies associated low muscle strength with age, disease activity, and fatigue. No associations were found in spondyloarthritis, and none were found in systemic sclerosis.
Conclusions and Implications
Patients with IMRD exhibit lower muscle strength than healthy counterparts, with low strength moderately associated with longer disease duration, worsening disease activity, and decline in physical function. Targeted interventions are crucial for preventing and managing muscle weakness in IMRDs.
期刊介绍:
JAMDA, the official journal of AMDA - The Society for Post-Acute and Long-Term Care Medicine, is a leading peer-reviewed publication that offers practical information and research geared towards healthcare professionals in the post-acute and long-term care fields. It is also a valuable resource for policy-makers, organizational leaders, educators, and advocates.
The journal provides essential information for various healthcare professionals such as medical directors, attending physicians, nurses, consultant pharmacists, geriatric psychiatrists, nurse practitioners, physician assistants, physical and occupational therapists, social workers, and others involved in providing, overseeing, and promoting quality