Caenorhabditis elegans CYP33 Family in Eicosanoid Regulation, Xenobiotic Metabolism, Nanotoxicity and Spermatogenesis.

IF 2.7 4区医学 Q3 TOXICOLOGY

Journal of Applied Toxicology Pub Date : 2024-10-04 DOI:10.1002/jat.4707

Sharoen Yu Ming Lim, Willone Lim, Angela Paul Peter, Yan Pan, Mustafa Alshagga, Mohammed Abdullah Alshawsh

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引用次数: 0

摘要

秀丽隐杆线虫中的 CYP33 家族与异生物解毒、类二十烷调节、纳米毒性反应和精子发生等过程密不可分。对 elegans CYP33 的有限研究表明，其功能与人类的 CYP33 相似，这表明它们在新陈代谢和疾病中的作用是一致的。这篇综述研究了 elegans CYP33 酶，特别是 CYP-33E1 和 CYP-33E2 以及它们的人类同源物，重点是它们在二十碳类固醇生物合成、异生物代谢、纳米毒性和精子发生中的作用。对这些酶的了解有助于加深对细胞色素 P450 生物学、新陈代谢和细胞色素相关疾病的认识。

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Caenorhabditis elegans CYP33 Family in Eicosanoid Regulation, Xenobiotic Metabolism, Nanotoxicity and Spermatogenesis.

The CYP33 family in Caenorhabditis elegans is integral to processes like xenobiotic detoxification, eicosanoid regulation, nanotoxicity response and spermatogenesis. Limited research on C. elegans CYP33 suggests its functions are similar to human CYP33, indicating conserved roles in metabolism and disease. This review examines C. elegans CYP33 enzymes, especially CYP-33E1 and CYP-33E2, and their human homologues, focusing on their roles in eicosanoid biosynthesis, xenobiotic metabolism, nanotoxicity and spermatogenesis. Understanding these enzymes enhances insights into cytochrome P450 biology, metabolism and cyp-associated diseases.

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来源期刊

Journal of Applied Toxicology 医学-毒理学

CiteScore

7.00

自引率

6.10%

发文量

145

审稿时长

1 months

期刊介绍： Journal of Applied Toxicology publishes peer-reviewed original reviews and hypothesis-driven research articles on mechanistic, fundamental and applied research relating to the toxicity of drugs and chemicals at the molecular, cellular, tissue, target organ and whole body level in vivo (by all relevant routes of exposure) and in vitro / ex vivo. All aspects of toxicology are covered (including but not limited to nanotoxicology, genomics and proteomics, teratogenesis, carcinogenesis, mutagenesis, reproductive and endocrine toxicology, toxicopathology, target organ toxicity, systems toxicity (eg immunotoxicity), neurobehavioral toxicology, mechanistic studies, biochemical and molecular toxicology, novel biomarkers, pharmacokinetics/PBPK, risk assessment and environmental health studies) and emphasis is given to papers of clear application to human health, and/or advance mechanistic understanding and/or provide significant contributions and impact to their field.