妊娠期高血糖妇女的特定种族口服葡萄糖耐量(OGTT)表型。

IF 3.7 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Yu Bin Tan, Phaik Ling Quah, Kok Hian Tan
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引用次数: 0

摘要

简介:与口服葡萄糖耐量试验(OGTT)表型相关的种族差异在东南亚种族中研究较少:东南亚人种中与口服葡萄糖耐量试验(OGTT)表型相关的种族差异研究较少,尤其是妊娠期高血糖(HIP)妇女:我们回顾性研究了 2019 年在 KK 妇女儿童医院就诊的 3027 名妇女。其中,508 名(16.8%)妇女在 24-28 周时根据 IADPSG(国际糖尿病和妊娠研究小组协会)标准被诊断为 HIP。根据(1) 仅 0 小时;(2) 仅 1 小时;(3) 仅 2 小时;(4) ≥ 2 个时间点(参考)的血浆葡萄糖异常,将 OGTT 表型分为四个互斥组。多项式逻辑回归用于研究种族与 OGTT 表型之间的关系,并对产妇年龄、胎次和第一胎体重指数进行了调整:结果:HIP 的总体患病率为 16.8%,其中印度人最高(20.5%),然后是华人(18.3%)和马来人(14.2%)。与马来人相比,印度人(相对风险比为 3.05)和华人(相对风险比为 2.33)出现仅禁食表型的风险更高。与马来人相比,华人出现餐后 2 小时表型的风险更高,相对风险比为 2.88:结论:在多种族的亚洲人群中,不同种族的 HIP 女性患者存在独特的 OGTT 表型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ethnic-specific oral glucose tolerance (OGTT) phenotypes in women with hyperglycemia in pregnancy.

Introduction: Ethnic differences associated with oral glucose tolerance test (OGTT) phenotypes is less studied in Southeast Asian ethnicities, especially in women with hyperglycemia in pregnancy (HIP).

Research design and methods: We retrospectively examined 3027 women at KK Women's and Children's Hospital in 2019. Of these, 508 (16.8%) women were diagnosed with HIP using the IADPSG (International Association of Diabetes and Pregnancy Study Groups) criteria at 24-28 weeks. OGTT phenotypes were classified into four mutually exclusive groups based on abnormal plasma glucose at (1) 0 hour only; (2) 1 hour only; (3) 2 hour only; (4) ≥2 timepoints (reference). Multinomial logistic regression was used to examine the association between ethnicity and OGTT phenotypes, adjusting for maternal age, parity, and first-trimester body mass index.

Results: Overall HIP prevalence was 16.8%, highest among Indians (20.5%), then Chinese (18.3%) and Malays (14.2%). Indians (relative risk ratio (RRR) 3.05) and Chinese (RRR 2.33) were at higher risk of displaying a fasting-only phenotype compared with Malays. Chinese were at increased risk of displaying a 2-hour postprandial phenotype with an RRR of 2.88 as compared with Malays.

Conclusions: Unique OGTT phenotypes exist across ethnic groups among women who developed HIP in a multi-ethnic Asian population.

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来源期刊
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
9.30
自引率
2.40%
发文量
123
审稿时长
18 weeks
期刊介绍: BMJ Open Diabetes Research & Care is an open access journal committed to publishing high-quality, basic and clinical research articles regarding type 1 and type 2 diabetes, and associated complications. Only original content will be accepted, and submissions are subject to rigorous peer review to ensure the publication of high-quality — and evidence-based — original research articles.
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