{"title":"高压氧疗法在急性肾损伤小鼠模型中的肾保护作用:系统综述和荟萃分析。","authors":"","doi":"10.1016/j.lfs.2024.123098","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>Acute kidney injury (AKI) is a life-threatening condition marked by sudden kidney function loss and azotemia. While its management is limited to supportive care, the effects of hyperbaric oxygen therapy (HBO) on AKI remain a subject of conflicting animal research. This study aimed to systematically review and meta-analyze HBO's effects on renal function biomarkers serum creatinine (SCr) and blood urea nitrogen (BUN) in murine AKI models, also exploring tissue-level nephroprotection.</div></div><div><h3>Main methods</h3><div>The PUBMED, SciELO, and LILACS databases were searched until September 5, 2024. Effect sizes of HBO on SCr and BUN levels were expressed as standardized mean difference (SMD) alongside 95 % confidence interval (CI), calculated by random-effects model. Extracted data also included murine specie/strain, HBO parameters, AKI induction method (toxic, ischemic, others), and histological findings. Study quality and publication bias were respectively assessed using the CAMARADES checklist and Egger's test. This review adhered to PRISMA guidelines and was registered in PROSPERO (CRD42022369804).</div></div><div><h3>Key findings</h3><div>Data synthesis from 21 studies demonstrates that HBO effectively reduces azotemia in AKI-affected animals (SCr's SMD = −1.69, 95 % CI = −2.38 to −0.99, <em>P</em> < 0.001; BUN's SMD = −1.51, 95 % CI = −2.32 to −0.71, P < 0.001) while mitigating histological damage. Subgroup analyses indicate that HBO particularly benefits ischemic and other AKI types (<em>P</em> < 0.05). In contrast, data from toxic AKI models were inconclusive due to insufficient statistical power (<em>P</em> > 0.05, 1-β < 30 %).</div></div><div><h3>Significance</h3><div>This meta-analysis provides compelling evidence supporting the adjunctive use of HBO in AKI management.</div></div>","PeriodicalId":18122,"journal":{"name":"Life sciences","volume":null,"pages":null},"PeriodicalIF":5.2000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nephroprotective effects of hyperbaric oxygen therapy in murine models of acute kidney injury: A systematic review and meta-analysis\",\"authors\":\"\",\"doi\":\"10.1016/j.lfs.2024.123098\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aims</h3><div>Acute kidney injury (AKI) is a life-threatening condition marked by sudden kidney function loss and azotemia. While its management is limited to supportive care, the effects of hyperbaric oxygen therapy (HBO) on AKI remain a subject of conflicting animal research. This study aimed to systematically review and meta-analyze HBO's effects on renal function biomarkers serum creatinine (SCr) and blood urea nitrogen (BUN) in murine AKI models, also exploring tissue-level nephroprotection.</div></div><div><h3>Main methods</h3><div>The PUBMED, SciELO, and LILACS databases were searched until September 5, 2024. Effect sizes of HBO on SCr and BUN levels were expressed as standardized mean difference (SMD) alongside 95 % confidence interval (CI), calculated by random-effects model. Extracted data also included murine specie/strain, HBO parameters, AKI induction method (toxic, ischemic, others), and histological findings. Study quality and publication bias were respectively assessed using the CAMARADES checklist and Egger's test. This review adhered to PRISMA guidelines and was registered in PROSPERO (CRD42022369804).</div></div><div><h3>Key findings</h3><div>Data synthesis from 21 studies demonstrates that HBO effectively reduces azotemia in AKI-affected animals (SCr's SMD = −1.69, 95 % CI = −2.38 to −0.99, <em>P</em> < 0.001; BUN's SMD = −1.51, 95 % CI = −2.32 to −0.71, P < 0.001) while mitigating histological damage. Subgroup analyses indicate that HBO particularly benefits ischemic and other AKI types (<em>P</em> < 0.05). In contrast, data from toxic AKI models were inconclusive due to insufficient statistical power (<em>P</em> > 0.05, 1-β < 30 %).</div></div><div><h3>Significance</h3><div>This meta-analysis provides compelling evidence supporting the adjunctive use of HBO in AKI management.</div></div>\",\"PeriodicalId\":18122,\"journal\":{\"name\":\"Life sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.2000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Life sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S002432052400688X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002432052400688X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
目的:急性肾损伤(AKI)是一种以肾功能突然丧失和氮质血症为特征的危及生命的疾病。虽然对急性肾损伤的治疗仅限于支持性护理,但高压氧疗法(HBO)对急性肾损伤的影响仍是一个相互矛盾的动物研究课题。本研究旨在系统回顾和荟萃分析高压氧治疗对小鼠 AKI 模型中肾功能生物标志物血清肌酐(SCr)和血尿素氮(BUN)的影响,同时探讨组织水平的肾保护作用:主要方法:检索 PUBMED、SciELO 和 LILACS 数据库,直至 2024 年 9 月 5 日。HBO对SCr和BUN水平的影响大小以标准化平均差(SMD)和95%置信区间(CI)表示,采用随机效应模型计算。提取的数据还包括小鼠种类/品系、HBO参数、AKI诱导方法(毒性、缺血性、其他)和组织学结果。研究质量和发表偏倚分别采用CAMARADES核对表和Egger检验进行评估。本综述遵循了 PRISMA 指南,并在 PROSPERO(CRD42022369804)上进行了注册:来自 21 项研究的数据综合显示,HBO 可有效降低受 AKI 影响动物的氮质血症(SCr's SMD = -1.69, 95 % CI = -2.38 to -0.99, P 0.05, 1-β 显著性):这项荟萃分析提供了令人信服的证据,支持在 AKI 治疗中辅助使用 HBO。
Nephroprotective effects of hyperbaric oxygen therapy in murine models of acute kidney injury: A systematic review and meta-analysis
Aims
Acute kidney injury (AKI) is a life-threatening condition marked by sudden kidney function loss and azotemia. While its management is limited to supportive care, the effects of hyperbaric oxygen therapy (HBO) on AKI remain a subject of conflicting animal research. This study aimed to systematically review and meta-analyze HBO's effects on renal function biomarkers serum creatinine (SCr) and blood urea nitrogen (BUN) in murine AKI models, also exploring tissue-level nephroprotection.
Main methods
The PUBMED, SciELO, and LILACS databases were searched until September 5, 2024. Effect sizes of HBO on SCr and BUN levels were expressed as standardized mean difference (SMD) alongside 95 % confidence interval (CI), calculated by random-effects model. Extracted data also included murine specie/strain, HBO parameters, AKI induction method (toxic, ischemic, others), and histological findings. Study quality and publication bias were respectively assessed using the CAMARADES checklist and Egger's test. This review adhered to PRISMA guidelines and was registered in PROSPERO (CRD42022369804).
Key findings
Data synthesis from 21 studies demonstrates that HBO effectively reduces azotemia in AKI-affected animals (SCr's SMD = −1.69, 95 % CI = −2.38 to −0.99, P < 0.001; BUN's SMD = −1.51, 95 % CI = −2.32 to −0.71, P < 0.001) while mitigating histological damage. Subgroup analyses indicate that HBO particularly benefits ischemic and other AKI types (P < 0.05). In contrast, data from toxic AKI models were inconclusive due to insufficient statistical power (P > 0.05, 1-β < 30 %).
Significance
This meta-analysis provides compelling evidence supporting the adjunctive use of HBO in AKI management.
期刊介绍:
Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed.
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