一种新型的保护和修复护肤方案显示出改善环境导致的皮肤老化的功效。

IF 1.5 4区 医学 Q3 DERMATOLOGY
Patricia K Farris, Zoe Diana Draelos, Yohei Tanaka, Vivian Bucay, Amaryllis Aganahi M Biotech, Natasha Ribeiro, Richard Parker
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引用次数: 0

摘要

背景:环境暴露(包括太阳辐射和污染物)会加速皮肤老化。目的:评估一种新型护肤方案的临床效果,该方案日间提供全面的环境保护,夜间修复受环境损害的皮肤:30名轻度至中度外在老化的男性和女性参加了为期12周的单点研究。参与者使用的护肤品(The Essential Six,RATIONALE,澳大利亚维多利亚州)包括 3 种产品,早上用于保护皮肤,晚上用于修复皮肤。参与者接受基线检查,并在第 2、6 和 12 周进行疗效和耐受性评估。对水合作用、经表皮失水、肤色和弹性进行了非侵入性测量:结果:皮肤科调查员注意到,除深层皱纹外,所有评估指标均有全面改善。第 12 周时,光泽度(43%)、触感粗糙度(48%)、视觉粗糙度(44%)、紧致度(32%)、透明度/肤色均匀度(21%)和整体外观(29%)均有显著改善(P<0.001)。第 12 周时,细纹改善了 16%(P=0.002)。参与者的自我评估显示,随着时间的推移,所有评估参数都有显著的统计学意义上的渐进改善。研究人员没有发现任何耐受性问题,但有少数参与者报告了轻微的刺痛感和一些干燥感,但随着时间的推移,这些问题都得到了解决。这可能是由于该护理方案中含有高浓度的活性成分。角膜测量显示,早在第 2 周,皮肤水合度就提高了 28%:结论:所提供的数据证实,这种新型的保护和修复方案能改善环境老化皮肤的外观。J Drugs Dermatol.2024;23(10):866-872. doi:10.36849/JDD.8274.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Novel Protection and Repair Skincare Regimen Shows Efficacy for Improving Environmental Skin Aging.

Background: Skin aging is accelerated by environmental exposures including solar radiation and pollutants. Thus, protecting skin from environmental exposure and repairing ensuing damage is essential for keeping skin healthy and appearing youthful.

Purpose: To evaluate the clinical benefits of a novel skincare regimen designed to provide comprehensive environmental protection in the daytime and repair environmentally damaged skin at night.

Methods: Thirty participants, including males and females, with mild-to-moderate extrinsic aging, were enrolled in a 12-week single-site study. Participants used the regimen (The Essential Six, RATIONALE, Victoria, Australia) comprised of 3 products to protect the skin in the morning and 3 products to repair the skin at night. Participants were seen at baseline and evaluated for efficacy and tolerability at weeks 2, 6, and 12. Non-invasive measurements to evaluate hydration, transepidermal water loss, skin tone, and elasticity were conducted.

Results: The dermatologist investigator noted across-the-board improvement in all evaluated parameters, except deep wrinkles. By week 12, there were statistically significant (P<0.001) improvements in radiance (43%), tactile roughness (48%), visual roughness (44%), firmness (32%), clarity/even skin tone (21%), and overall appearance (29%). Fine lines improved 16% at week 12 (P=0.002). Participant self-assessment revealed statistically significant and progressive improvement in all evaluated parameters over time. No tolerability issues were identified by the investigator, while a small number of participants reported mild stinging and some dryness that resolved over time. This was likely due to the high concentration of active ingredients found in this regimen. Corneometry revealed improved skin hydration of 28% as early as week 2.

Conclusion: The data presented confirms that this novel protection and repair regimen improves the appearance of environmentally aged skin. J Drugs Dermatol. 2024;23(10):866-872. doi:10.36849/JDD.8274.

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来源期刊
CiteScore
2.20
自引率
13.30%
发文量
289
审稿时长
3-6 weeks
期刊介绍: The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology. We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality. Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.
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