评估和减轻大规模组学研究中的批次效应

IF 10.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genome Biology Pub Date : 2024-10-03 DOI:10.1186/s13059-024-03401-9

Ying Yu, Yuanbang Mai, Yuanting Zheng, Leming Shi

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引用次数: 0

摘要

众所周知，omics 数据中的批次效应是与研究目标无关的常见技术变异，如果不加以校正，可能会导致误导性结果，如果校正过度，则会阻碍生物医学发现。评估和减轻批次效应对于确保 omics 数据的可靠性和可重复性以及最大限度地减少技术变异对生物学解释的影响至关重要。在这篇综述中，我们强调了批次效应的深远负面影响，以及在大规模 omics 研究中解决这一挑战性问题的迫切需要。我们总结了批次效应的潜在来源、评估和纠正批次效应的当前进展以及旨在解决批次效应的联合努力。

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Assessing and mitigating batch effects in large-scale omics studies

Batch effects in omics data are notoriously common technical variations unrelated to study objectives, and may result in misleading outcomes if uncorrected, or hinder biomedical discovery if over-corrected. Assessing and mitigating batch effects is crucial for ensuring the reliability and reproducibility of omics data and minimizing the impact of technical variations on biological interpretation. In this review, we highlight the profound negative impact of batch effects and the urgent need to address this challenging problem in large-scale omics studies. We summarize potential sources of batch effects, current progress in evaluating and correcting them, and consortium efforts aiming to tackle them.

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来源期刊

Genome Biology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

21.00

自引率

3.30%

发文量

241

审稿时长

2 months

期刊介绍： Genome Biology stands as a premier platform for exceptional research across all domains of biology and biomedicine, explored through a genomic and post-genomic lens. With an impressive impact factor of 12.3 (2022),* the journal secures its position as the 3rd-ranked research journal in the Genetics and Heredity category and the 2nd-ranked research journal in the Biotechnology and Applied Microbiology category by Thomson Reuters. Notably, Genome Biology holds the distinction of being the highest-ranked open-access journal in this category. Our dedicated team of highly trained in-house Editors collaborates closely with our esteemed Editorial Board of international experts, ensuring the journal remains on the forefront of scientific advances and community standards. Regular engagement with researchers at conferences and institute visits underscores our commitment to staying abreast of the latest developments in the field.