抑郁和血浆 pTau181 水平与西班牙裔社区老年妇女的虚弱状态有关。

IF 2.1 Q3 GERIATRICS & GERONTOLOGY
Gerontology and Geriatric Medicine Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI:10.1177/23337214241283546
Giselle A Rangel, Adam E Tratner, Diana C Oviedo, Alcibiades E Villarreal, Maria B Carreira, Sofia Rodriguez-Araña, Eugenia Flores Millender, Casey Xavier Hall, Frank Y Wong, Sid O'Bryant, Gabrielle B Britton
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引用次数: 0

摘要

随着慢性病负担的加重,西班牙裔老年人口也在不断增长。这项横断面研究旨在评估参加巴拿马老龄化研究计划--健康差异研究(Panama Aging Research Initiative-Health Disparities)的巴拿马老年人认知功能健康研究的 60 岁以上居住在社区的西班牙裔女性(n = 357)中与虚弱有关的因素。认知功能通过神经心理学测试进行评估。抑郁采用老年抑郁量表进行测量。虚弱的定义采用弗里德标准,参与者被分为非虚弱、前期虚弱或虚弱。一个子样本(n = 281)提供了空腹血液样本,用于量化蛋白质生物标志物。采用分层多元线性回归法检验了两者之间的关联。59.4%和9.0%的参与者(M = 69.2岁,SD = 6.3)分别属于前期衰弱和后期衰弱。抑郁程度越高(β = .28,p = .039),α2M 水平越高,虚弱程度越低(β = -.16,p = .004)。这些发现推动了对虚弱的健康指标和生物标志物的研究,值得进一步研究,以减轻西班牙裔老年妇女的虚弱负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Depression and Plasma pTau181 Levels Are Associated with Frailty Status in Hispanic Community-Dwelling Older Women.

The population of Hispanic older adults is growing along with the burden of chronic diseases. This cross-sectional study aims to assess the factors associated with frailty among community-dwelling Hispanic women aged ≥60 years (n = 357) enrolled in the Panama Aging Research Initiative-Health Disparities study of cognitive-functional health of older persons in Panama. Cognitive function was assessed with a neuropsychological test battery. Depression was measured with the Geriatric Depression Scale. Frailty was defined using the Fried criteria and participants were classified as non-frail, pre-frail or frail. A subsample (n = 281) provided fasting blood samples for quantification of protein biomarkers. Associations were examined using hierarchical multiple linear regressions. 59.4% and 9.0% of participants (M = 69.2 years, SD = 6.3) were pre-frail and frail, respectively. Having more depression (β = .28, p < .001) was significantly associated with frailty, even after covariate adjustment. Cognitive function was not associated with frailty. Higher pTau181 levels were associated with increased frailty (β = .13, p = .039), whereas higher α2M levels were associated with decreased frailty (β = -.16, p = .004). These findings advance the search for health indicators and biomarkers of frailty and warrant further studies to decrease the burden of frailty among older Hispanic women.

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来源期刊
Gerontology and Geriatric Medicine
Gerontology and Geriatric Medicine Medicine-Geriatrics and Gerontology
CiteScore
2.90
自引率
3.70%
发文量
119
审稿时长
12 weeks
期刊介绍: Gerontology and Geriatric Medicine (GGM) is an interdisciplinary, peer-reviewed open access journal where scholars from a variety of disciplines present their work focusing on the psychological, behavioral, social, and biological aspects of aging, and public health services and research related to aging. The journal addresses a wide variety of topics related to health services research in gerontology and geriatrics. GGM seeks to be one of the world’s premier Open Access outlets for gerontological academic research. As such, GGM does not limit content due to page budgets or thematic significance. Papers will be subjected to rigorous peer review but will be selected solely on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, GGM facilitates the discovery of the connections between papers.
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