Giselle A Rangel, Adam E Tratner, Diana C Oviedo, Alcibiades E Villarreal, Maria B Carreira, Sofia Rodriguez-Araña, Eugenia Flores Millender, Casey Xavier Hall, Frank Y Wong, Sid O'Bryant, Gabrielle B Britton
{"title":"抑郁和血浆 pTau181 水平与西班牙裔社区老年妇女的虚弱状态有关。","authors":"Giselle A Rangel, Adam E Tratner, Diana C Oviedo, Alcibiades E Villarreal, Maria B Carreira, Sofia Rodriguez-Araña, Eugenia Flores Millender, Casey Xavier Hall, Frank Y Wong, Sid O'Bryant, Gabrielle B Britton","doi":"10.1177/23337214241283546","DOIUrl":null,"url":null,"abstract":"<p><p>The population of Hispanic older adults is growing along with the burden of chronic diseases. This cross-sectional study aims to assess the factors associated with frailty among community-dwelling Hispanic women aged ≥60 years (<i>n</i> = 357) enrolled in the Panama Aging Research Initiative-Health Disparities study of cognitive-functional health of older persons in Panama. Cognitive function was assessed with a neuropsychological test battery. Depression was measured with the Geriatric Depression Scale. Frailty was defined using the Fried criteria and participants were classified as non-frail, pre-frail or frail. A subsample (<i>n</i> = 281) provided fasting blood samples for quantification of protein biomarkers. Associations were examined using hierarchical multiple linear regressions. 59.4% and 9.0% of participants (<i>M</i> = 69.2 years, <i>SD</i> = 6.3) were pre-frail and frail, respectively. Having more depression (β = .28, <i>p</i> < .001) was significantly associated with frailty, even after covariate adjustment. Cognitive function was not associated with frailty. Higher pTau181 levels were associated with increased frailty (β = .13, <i>p</i> = .039), whereas higher α2M levels were associated with decreased frailty (β = -.16, <i>p</i> = .004). These findings advance the search for health indicators and biomarkers of frailty and warrant further studies to decrease the burden of frailty among older Hispanic women.</p>","PeriodicalId":52146,"journal":{"name":"Gerontology and Geriatric Medicine","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445770/pdf/","citationCount":"0","resultStr":"{\"title\":\"Depression and Plasma pTau<sub>181</sub> Levels Are Associated with Frailty Status in Hispanic Community-Dwelling Older Women.\",\"authors\":\"Giselle A Rangel, Adam E Tratner, Diana C Oviedo, Alcibiades E Villarreal, Maria B Carreira, Sofia Rodriguez-Araña, Eugenia Flores Millender, Casey Xavier Hall, Frank Y Wong, Sid O'Bryant, Gabrielle B Britton\",\"doi\":\"10.1177/23337214241283546\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The population of Hispanic older adults is growing along with the burden of chronic diseases. This cross-sectional study aims to assess the factors associated with frailty among community-dwelling Hispanic women aged ≥60 years (<i>n</i> = 357) enrolled in the Panama Aging Research Initiative-Health Disparities study of cognitive-functional health of older persons in Panama. Cognitive function was assessed with a neuropsychological test battery. Depression was measured with the Geriatric Depression Scale. Frailty was defined using the Fried criteria and participants were classified as non-frail, pre-frail or frail. A subsample (<i>n</i> = 281) provided fasting blood samples for quantification of protein biomarkers. Associations were examined using hierarchical multiple linear regressions. 59.4% and 9.0% of participants (<i>M</i> = 69.2 years, <i>SD</i> = 6.3) were pre-frail and frail, respectively. Having more depression (β = .28, <i>p</i> < .001) was significantly associated with frailty, even after covariate adjustment. Cognitive function was not associated with frailty. Higher pTau181 levels were associated with increased frailty (β = .13, <i>p</i> = .039), whereas higher α2M levels were associated with decreased frailty (β = -.16, <i>p</i> = .004). These findings advance the search for health indicators and biomarkers of frailty and warrant further studies to decrease the burden of frailty among older Hispanic women.</p>\",\"PeriodicalId\":52146,\"journal\":{\"name\":\"Gerontology and Geriatric Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445770/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gerontology and Geriatric Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/23337214241283546\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gerontology and Geriatric Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/23337214241283546","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Depression and Plasma pTau181 Levels Are Associated with Frailty Status in Hispanic Community-Dwelling Older Women.
The population of Hispanic older adults is growing along with the burden of chronic diseases. This cross-sectional study aims to assess the factors associated with frailty among community-dwelling Hispanic women aged ≥60 years (n = 357) enrolled in the Panama Aging Research Initiative-Health Disparities study of cognitive-functional health of older persons in Panama. Cognitive function was assessed with a neuropsychological test battery. Depression was measured with the Geriatric Depression Scale. Frailty was defined using the Fried criteria and participants were classified as non-frail, pre-frail or frail. A subsample (n = 281) provided fasting blood samples for quantification of protein biomarkers. Associations were examined using hierarchical multiple linear regressions. 59.4% and 9.0% of participants (M = 69.2 years, SD = 6.3) were pre-frail and frail, respectively. Having more depression (β = .28, p < .001) was significantly associated with frailty, even after covariate adjustment. Cognitive function was not associated with frailty. Higher pTau181 levels were associated with increased frailty (β = .13, p = .039), whereas higher α2M levels were associated with decreased frailty (β = -.16, p = .004). These findings advance the search for health indicators and biomarkers of frailty and warrant further studies to decrease the burden of frailty among older Hispanic women.
期刊介绍:
Gerontology and Geriatric Medicine (GGM) is an interdisciplinary, peer-reviewed open access journal where scholars from a variety of disciplines present their work focusing on the psychological, behavioral, social, and biological aspects of aging, and public health services and research related to aging. The journal addresses a wide variety of topics related to health services research in gerontology and geriatrics. GGM seeks to be one of the world’s premier Open Access outlets for gerontological academic research. As such, GGM does not limit content due to page budgets or thematic significance. Papers will be subjected to rigorous peer review but will be selected solely on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, GGM facilitates the discovery of the connections between papers.