Masafumi Horie, Yoshiyuki Akiyama, Hiroto Katoh, Satoru Taguchi, Masaki Nakamura, Keishi Mizuguchi, Yukinobu Ito, Takashi Matsushita, Tetsuo Ushiku, Shumpei Ishikawa, Akiteru Goto, Haruki Kume, Yukio Homma, Daichi Maeda
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{"title":"APRIL/BAFF上调与Hunner型间质性膀胱炎的克隆B细胞扩增有关。","authors":"Masafumi Horie, Yoshiyuki Akiyama, Hiroto Katoh, Satoru Taguchi, Masaki Nakamura, Keishi Mizuguchi, Yukinobu Ito, Takashi Matsushita, Tetsuo Ushiku, Shumpei Ishikawa, Akiteru Goto, Haruki Kume, Yukio Homma, Daichi Maeda","doi":"10.1002/path.6353","DOIUrl":null,"url":null,"abstract":"<p>Hunner-type interstitial cystitis (HIC) is a chronic inflammatory disease of the urinary bladder with an unknown etiology. We conducted comprehensive immunogenomic profiling of bladder specimens obtained by biopsy and cystectomy from 37 patients with HIC. Next-generation RNA sequencing demonstrated abundant plasma cell infiltration with frequent light chain restriction in HIC-affected bladder tissue. Subsequent analysis of the B-cell receptor repertoire revealed spatial and temporal expansion of B-cell clones. The extent of B-cell clonal expansion was significantly correlated with the gene expression levels of <i>TNFSF13</i> and <i>TNFSF13B</i>, which encode APRIL and BAFF, respectively. These findings indicate that APRIL and BAFF are the key regulators of clonal B-cell expansion in HIC and might serve as therapeutic targets in this debilitating disease. © 2024 The Author(s). <i>The Journal of Pathology</i> published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.</p>","PeriodicalId":232,"journal":{"name":"The Journal of Pathology","volume":"264 4","pages":"383-395"},"PeriodicalIF":5.6000,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/path.6353","citationCount":"0","resultStr":"{\"title\":\"APRIL/BAFF upregulation is associated with clonal B-cell expansion in Hunner-type interstitial cystitis\",\"authors\":\"Masafumi Horie, Yoshiyuki Akiyama, Hiroto Katoh, Satoru Taguchi, Masaki Nakamura, Keishi Mizuguchi, Yukinobu Ito, Takashi Matsushita, Tetsuo Ushiku, Shumpei Ishikawa, Akiteru Goto, Haruki Kume, Yukio Homma, Daichi Maeda\",\"doi\":\"10.1002/path.6353\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Hunner-type interstitial cystitis (HIC) is a chronic inflammatory disease of the urinary bladder with an unknown etiology. We conducted comprehensive immunogenomic profiling of bladder specimens obtained by biopsy and cystectomy from 37 patients with HIC. Next-generation RNA sequencing demonstrated abundant plasma cell infiltration with frequent light chain restriction in HIC-affected bladder tissue. Subsequent analysis of the B-cell receptor repertoire revealed spatial and temporal expansion of B-cell clones. The extent of B-cell clonal expansion was significantly correlated with the gene expression levels of <i>TNFSF13</i> and <i>TNFSF13B</i>, which encode APRIL and BAFF, respectively. These findings indicate that APRIL and BAFF are the key regulators of clonal B-cell expansion in HIC and might serve as therapeutic targets in this debilitating disease. © 2024 The Author(s). <i>The Journal of Pathology</i> published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.</p>\",\"PeriodicalId\":232,\"journal\":{\"name\":\"The Journal of Pathology\",\"volume\":\"264 4\",\"pages\":\"383-395\"},\"PeriodicalIF\":5.6000,\"publicationDate\":\"2024-10-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/path.6353\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/path.6353\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Pathology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/path.6353","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
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