Michael Eyre, Michael Absoud, Omar Abdel-Mannan, Sarah Crichton, Yael Hacohen, Thomas Rossor, Sarah Rudebeck, Gavin Giovannoni, Ming Lim, Cheryl Hemingway
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引用次数: 0
摘要
在儿科获得性脱髓鞘综合征临床发病之前，认知能力是否会受损尚不清楚。我们利用前瞻性收集的教育数据，对多发性硬化症（MS）和髓鞘少突胶质细胞糖蛋白抗体病（MOGAD）患者（n = 60）和对照组（合计 n = 449,553 人）进行了一项匹配队列研究。多发性硬化症和髓鞘少突胶质细胞糖蛋白抗体病（MOGAD）患者 10-11 岁时的学习成绩受损（调整后 Z 评分为-1.27 [95% CI：-1.81 至-0.73]，P<0.05）。
Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study.
It is unknown if cognition is impaired before clinical onset of paediatric acquired demyelinating syndromes. We conducted a matched cohort study using prospectively collected educational data in multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) patients (n = 60) and controls (pooled n = 449,553). Academic performance at ages 10-11 was impaired in MOGAD (-1.27 adjusted z-score [95% CI: -1.81 to -0.73], P < 0.001) and preclinical MS (-0.40 [-0.80 to -0.0003], P = 0.0498). Moderate/high-efficacy MS treatment was associated with better final academic performance (0.92 [0.28-1.57], P = 0.005). After clinical onset MS patients missed 8.7% of school (controls 2.9%, P < 0.001) and MOGAD patients 11.9% (controls 2.0%, P < 0.001).
期刊介绍：
Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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