比伐卢定作为儿童急性血液透析的抗凝策略:两个病例及最新文献综述。

IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY
Tanguy Viaene, Evelyn Dhont, Floris Vanommeslaeghe, Sunny Eloot, Filip De Somer, Jonathan De Rudder, Veerle Mondelaers, Evelien Snauwaert
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引用次数: 0

摘要

在儿童体外透析(包括急性血液透析)中,最常用的抗凝剂是非减量肝素。在某些情况下,如肝素诱导的血小板减少症,必须使用替代品。直接凝血酶抑制剂比伐卢定已成为一种极具吸引力的替代品。目前,比伐卢定只被批准在特定的经皮冠状动脉介入治疗中用于成人。不过,它在成人和儿童患者的不同情况下的标示外使用越来越受欢迎。在儿童中使用比伐卢定的经验主要局限于体外膜氧合、心室辅助装置和心肺旁路手术。有关在儿童血液透析中使用比伐卢定作为抗凝策略的文献非常少。在此,我们介绍两例在急性血液透析期间使用比伐卢定的儿科病例,并对近期文献进行简要总结。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bivalirudin as an anticoagulation strategy for acute hemodialysis in children: Two cases with a summary of recent literature

Unfractionated heparin is the most used anticoagulative agent for extracorporeal settings in children, including acute hemodialysis modalities. In certain situations, such as heparin-induced thrombocytopenia, alternatives must be applied. The direct thrombin inhibitor bivalirudin has come forth as an attractive substitute. Bivalirudin is currently only approved for adult use in specific percutaneous coronary intervention settings. However, it has a growing off-label popularity in different contexts for both adult and pediatric patients. Experience with bivalirudin in children is mainly limited to extracorporeal membrane oxygenation, ventricular assist devices and during cardiopulmonary bypass surgery. Literature about its use as anticoagulation strategy for pediatric hemodialysis is very scarce. Here, we present two pediatric cases where bivalirudin was used during acute hemodialysis, followed by a short summary of recent literature.

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来源期刊
Hemodialysis International
Hemodialysis International UROLOGY & NEPHROLOGY-
CiteScore
2.50
自引率
0.00%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Hemodialysis International was originally an annual publication containing the Proceedings of the International Symposium on Hemodialysis held in conjunction with the Annual Dialysis Conference. Since 2003, Hemodialysis International is published quarterly and contains original papers on clinical and experimental topics related to dialysis in addition to the Annual Dialysis Conference supplement. This journal is a must-have for nephrologists, nurses, and technicians worldwide. Quarterly issues of Hemodialysis International are included with your membership to the International Society for Hemodialysis. The journal contains original articles, review articles, and commentary to keep readers completely updated in the field of hemodialysis. Edited by international and multidisciplinary experts, Hemodialysis International disseminates critical information in the field.
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