精神分裂症和类风湿性关节炎的基因图谱:可能与这两种疾病有关的非 HLA 基因。

IF 2.5 3区 工程技术 Q2 BIOLOGY
Yale Journal of Biology and Medicine Pub Date : 2024-09-30 eCollection Date: 2024-09-01 DOI:10.59249/FBOT5313
Nur Shafawati Ab Rajab, Mohd Azhar Mohd Yasin, Wan Syamimee Wan Ghazali, Norlelawati Abdul Talib, Wan Rohani Wan Taib, Sarina Sulong
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引用次数: 0

摘要

背景:长期以来,类风湿性关节炎(RA)与精神分裂症(SZ)之间的联系一直是各领域科学家讨论的热门话题。特别是在遗传学方面,RA 和 SZ 之间的联系仍有待讨论,这一点在本研究中可以看到。在确定这两种疾病之间的联系时,HLA 基因最受争议,但如果对其他可能被忽视的基因进行更深入的调查,可能会发现更有趣的东西。因此,要找到导致这种长期寻找的关系的基因,就必须寻找这些基因。材料与方法:从四个数据库中提取 SZ 和 RA 之间共有和重叠的相关基因。使用注释、可视化和综合发现数据库(DAVID)和InnateDB对重叠基因进行研究,以搜索这两种疾病之间的相关基因。结果发现结果:共发现了91个重叠基因,其中13个基因分为两组,显示出功能上的相似性,表明它们可能是一个重要的交汇点。FCGR2A、IL18R、BTNL2、AGER和CTLA4是5个与免疫系统相关的非HLA基因,这可能会导致对这两种疾病之间联系的新发现。结论深入研究这些在功能上具有可比性的非 HLA 重叠基因可能会揭示这两种疾病的新的有趣信息。了解RA和SZ的分子和免疫相关方面可能会揭示它们的病因,并为未来的靶向治疗策略研究提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Schizophrenia and Rheumatoid Arthritis Genetic Scenery: Potential Non-HLA Genes Involved in Both Diseases Relationship.

Background: The link between rheumatoid arthritis (RA) and schizophrenia (SZ) has long been a hot topic of deliberation among scientists from various fields. Especially when it comes to genetics, the connection between RA and SZ is still up for discussion, as can be observed in this study. The HLA genes are the most disputed in identifying a connection between the two diseases, but a more thorough investigation of other genes that may be ignored could yield something even more interesting. Thus, finding the genes responsible for this long-sought relationship will necessitate looking for them. Materials and Methods: Shared and overlapped associated genes involved between SZ and RA were extracted from four databases. The overlapping genes were examined using Database for Annotation, Visualization and Integrated Discovery (DAVID) and InnateDB to search the pertinent genes that concatenate between these two disorders. Results: A total of 91 overlapped genes were discovered, and that 13 genes, divided into two clusters, showed a similarity in function, suggesting that they may serve as an important meeting point. FCGR2A, IL18R, BTNL2, AGER, and CTLA4 are five non-HLA genes related to the immune system, which could lead to new discoveries about the connection between these two disorders. Conclusion: An in-depth investigation of these functionally comparable non-HLA genes that overlap could reveal new interesting information in both diseases. Understanding the molecular and immune-related aspects of RA and SZ may shed light on their etiology and inform future research on targeted treatment strategies.

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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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