重度抑郁症患者的欧米伽-3 多不饱和脂肪酸和血脑屏障完整性:恢复神经炎症和神经保护的平衡。

IF 2.5 3区 工程技术 Q2 BIOLOGY
Yale Journal of Biology and Medicine Pub Date : 2024-09-30 eCollection Date: 2024-09-01 DOI:10.59249/YZLQ4631
Halliru Zailani, Wen-Lung Wang, Senthil Kumaran Satyanarayanan, Wei-Che Chiu, Wen-Chun Liu, Yi-Shan Sung, Jane Pei-Chen Chang, Kuan-Pin Su
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引用次数: 0

摘要

重度抑郁症(MDD)影响着全球超过 2.64 亿人,它与免疫系统失调和慢性神经炎症有关,可能与神经退行性过程有关。本综述探讨了 MDD 中的血脑屏障(BBB)功能障碍,重点关注基质金属蛋白酶 9(MMP9)、水通道蛋白-4(AQP4)和 ATP 结合盒 B 亚家族成员 1(ABCB1)等关键调控因子。我们探讨了 MDD 中 BBB完整性受损可能导致神经炎症的潜在机制,并讨论了欧米伽-3 多不饱和脂肪酸(n-3 PUFAs)的治疗潜力。n-3 PUFAs 具有抗炎和保护神经的作用,并具有调节 MMP9、AQP4 和 ABCB1 的潜在能力,从而恢复 MDD 中 BBB 的完整性。本综述旨在阐明这些潜在机制,并评估 n-3 PUFAs 作为缓解 MDD 中 BBB 功能障碍和神经炎症的策略的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Omega-3 Polyunsaturated Fatty Acids and Blood-Brain Barrier Integrity in Major Depressive Disorder: Restoring Balance for Neuroinflammation and Neuroprotection.

Major depressive disorder (MDD), affecting over 264 million individuals globally, is associated with immune system dysregulation and chronic neuroinflammation, potentially linked to neurodegenerative processes. This review examines blood-brain barrier (BBB) dysfunction in MDD, focusing on key regulators like matrix metalloproteinase 9 (MMP9), aquaporin-4 (AQP4), and ATP-binding cassette subfamily B member 1 (ABCB1). We explore potential mechanisms by which compromised BBB integrity in MDD may contribute to neuroinflammation and discuss the therapeutic potential of omega-3 polyunsaturated fatty acids (n-3 PUFAs). n-3 PUFAs have demonstrated anti-inflammatory and neuroprotective effects, and potential ability to modulate MMP9, AQP4, and ABCB1, thereby restoring BBB integrity in MDD. This review aims to elucidate these potential mechanisms and evaluate the evidence for n-3 PUFAs as a strategy to mitigate BBB dysfunction and neuroinflammation in MDD.

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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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