病毒性社区获得性肺炎患者接受皮质类固醇治疗的效果。

IF 8.5 Q1 RESPIRATORY SYSTEM
Catia Cilloniz, Amedeo Guzzardella, Davide Calabretta, Albert Gabarrus, Maria Angeles Marcos, Antoni Torres
{"title":"病毒性社区获得性肺炎患者接受皮质类固醇治疗的效果。","authors":"Catia Cilloniz, Amedeo Guzzardella, Davide Calabretta, Albert Gabarrus, Maria Angeles Marcos, Antoni Torres","doi":"10.1186/s41479-024-00146-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>The objective of this study was to assess the therapeutic effects of corticosteroids in adult patients hospitalized with viral community-acquired pneumonia.</p><p><strong>Methods: </strong>This is a retrospective analysis of data collected prospectively from November 1996 to June 2024. All adult patients with viral community-acquired pneumonia were enrolled. The primary outcome was 30-day mortality. Secondary outcomes included all-cause in-hospital mortality, ICU admission, length of ICU and hospital stay, mechanical ventilation, and 1-year mortality. Propensity score matching (PSM) was used to obtain balance among the baseline variables in the two groups.</p><p><strong>Results: </strong>Of the 524 patients with viral pneumonia, 30 (6%) received corticosteroids and 494 (94%) did not. Patients were primarily male (n = 299, 57%), with a median [Q1-Q3] age of 66.9 [55-81] years. The 3:1 propensity matching procedure identified 90 patients not treated with corticosteroid (CS-) as controls. After PSM, no difference in 30-day mortality was found [7% (95%CI 1 to 22%) vs. 4% (95%CI 1 to 11%), p = 0.639]. The risk of death at 30 days did not differ significantly in unmatched and matched cohorts [Hazard Ratio (HR) 1.33 (0.32-5.63), p = 0.695 vs. HR 1.51 (0.28-8.27), p = 0.632, respectively]. Nor were differences found in hospital length of stay, ICU admission and length of stay, or mechanical ventilation requirement and duration between matched and unmatched CS + and CS-.</p><p><strong>Conclusions: </strong>There were no significant differences in the primary and secondary outcomes regarding the use of corticosteroids in patients with viral pneumonia.</p>","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":null,"pages":null},"PeriodicalIF":8.5000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423511/pdf/","citationCount":"0","resultStr":"{\"title\":\"Outcomes of corticosteroid therapy in patients with viral community-acquired pneumonia.\",\"authors\":\"Catia Cilloniz, Amedeo Guzzardella, Davide Calabretta, Albert Gabarrus, Maria Angeles Marcos, Antoni Torres\",\"doi\":\"10.1186/s41479-024-00146-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>The objective of this study was to assess the therapeutic effects of corticosteroids in adult patients hospitalized with viral community-acquired pneumonia.</p><p><strong>Methods: </strong>This is a retrospective analysis of data collected prospectively from November 1996 to June 2024. All adult patients with viral community-acquired pneumonia were enrolled. The primary outcome was 30-day mortality. Secondary outcomes included all-cause in-hospital mortality, ICU admission, length of ICU and hospital stay, mechanical ventilation, and 1-year mortality. Propensity score matching (PSM) was used to obtain balance among the baseline variables in the two groups.</p><p><strong>Results: </strong>Of the 524 patients with viral pneumonia, 30 (6%) received corticosteroids and 494 (94%) did not. Patients were primarily male (n = 299, 57%), with a median [Q1-Q3] age of 66.9 [55-81] years. The 3:1 propensity matching procedure identified 90 patients not treated with corticosteroid (CS-) as controls. After PSM, no difference in 30-day mortality was found [7% (95%CI 1 to 22%) vs. 4% (95%CI 1 to 11%), p = 0.639]. The risk of death at 30 days did not differ significantly in unmatched and matched cohorts [Hazard Ratio (HR) 1.33 (0.32-5.63), p = 0.695 vs. HR 1.51 (0.28-8.27), p = 0.632, respectively]. Nor were differences found in hospital length of stay, ICU admission and length of stay, or mechanical ventilation requirement and duration between matched and unmatched CS + and CS-.</p><p><strong>Conclusions: </strong>There were no significant differences in the primary and secondary outcomes regarding the use of corticosteroids in patients with viral pneumonia.</p>\",\"PeriodicalId\":45120,\"journal\":{\"name\":\"Pneumonia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.5000,\"publicationDate\":\"2024-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423511/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pneumonia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s41479-024-00146-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pneumonia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s41479-024-00146-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0

摘要

目的:本研究旨在评估皮质类固醇对因病毒性社区获得性肺炎住院的成人患者的治疗效果:本研究对 1996 年 11 月至 2024 年 6 月期间收集的前瞻性数据进行了回顾性分析。所有患有病毒性社区获得性肺炎的成人患者均被纳入研究。主要结果是 30 天死亡率。次要结局包括全因院内死亡率、入住重症监护室、重症监护室和住院时间、机械通气和 1 年死亡率。采用倾向评分匹配法(PSM)来平衡两组患者的基线变量:在 524 名病毒性肺炎患者中,30 人(6%)接受了皮质类固醇治疗,494 人(94%)未接受治疗。患者主要为男性(n = 299,57%),中位年龄[Q1-Q3]为 66.9 [55-81] 岁。通过 3:1 倾向匹配程序确定了 90 名未接受皮质类固醇治疗的患者(CS-)作为对照组。经过倾向匹配后,发现30天死亡率无差异[7%(95%CI 1-22%) vs. 4%(95%CI 1-11%),p = 0.639]。未配对队列和配对队列的 30 天死亡风险差异不大[危险比 (HR) 分别为 1.33 (0.32-5.63),p = 0.695 vs. HR 1.51 (0.28-8.27),p = 0.632]。在住院时间、入住 ICU 和住院时间、机械通气需求和持续时间方面,配对和未配对的 CS + 和 CS- 之间也未发现差异:病毒性肺炎患者使用皮质类固醇的主要和次要结果没有明显差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Outcomes of corticosteroid therapy in patients with viral community-acquired pneumonia.

Aim: The objective of this study was to assess the therapeutic effects of corticosteroids in adult patients hospitalized with viral community-acquired pneumonia.

Methods: This is a retrospective analysis of data collected prospectively from November 1996 to June 2024. All adult patients with viral community-acquired pneumonia were enrolled. The primary outcome was 30-day mortality. Secondary outcomes included all-cause in-hospital mortality, ICU admission, length of ICU and hospital stay, mechanical ventilation, and 1-year mortality. Propensity score matching (PSM) was used to obtain balance among the baseline variables in the two groups.

Results: Of the 524 patients with viral pneumonia, 30 (6%) received corticosteroids and 494 (94%) did not. Patients were primarily male (n = 299, 57%), with a median [Q1-Q3] age of 66.9 [55-81] years. The 3:1 propensity matching procedure identified 90 patients not treated with corticosteroid (CS-) as controls. After PSM, no difference in 30-day mortality was found [7% (95%CI 1 to 22%) vs. 4% (95%CI 1 to 11%), p = 0.639]. The risk of death at 30 days did not differ significantly in unmatched and matched cohorts [Hazard Ratio (HR) 1.33 (0.32-5.63), p = 0.695 vs. HR 1.51 (0.28-8.27), p = 0.632, respectively]. Nor were differences found in hospital length of stay, ICU admission and length of stay, or mechanical ventilation requirement and duration between matched and unmatched CS + and CS-.

Conclusions: There were no significant differences in the primary and secondary outcomes regarding the use of corticosteroids in patients with viral pneumonia.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Pneumonia
Pneumonia RESPIRATORY SYSTEM-
自引率
1.50%
发文量
7
审稿时长
11 weeks
期刊介绍:
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信