Adinei Abadio Soares, Helamã Moraes Dos Santos, Keyllor Nunes Domann, Natália Pratis Rocha Alves, Bernardo Ribeiro Böhm, Carolina Maliska Haack, Kailane Paula Pretto, Emily Sanini Guimarães, Guilherme Francisquini Rocha, Igor Rodrigues de Paula, Lucas Efraim de Alcântara Guimarães, Harlan Cleyton de Ávila Pessoa, Robison David Rodrigues, Angela Makeli Kososki Dalagnol, Marcelo Lemos Vieira da Cunha, Débora Tavares de Resende E Silva
{"title":"中枢神经系统原发性肿瘤中的嘌呤和嘌呤能受体。","authors":"Adinei Abadio Soares, Helamã Moraes Dos Santos, Keyllor Nunes Domann, Natália Pratis Rocha Alves, Bernardo Ribeiro Böhm, Carolina Maliska Haack, Kailane Paula Pretto, Emily Sanini Guimarães, Guilherme Francisquini Rocha, Igor Rodrigues de Paula, Lucas Efraim de Alcântara Guimarães, Harlan Cleyton de Ávila Pessoa, Robison David Rodrigues, Angela Makeli Kososki Dalagnol, Marcelo Lemos Vieira da Cunha, Débora Tavares de Resende E Silva","doi":"10.1007/s11302-024-10053-8","DOIUrl":null,"url":null,"abstract":"<p><p>Purine nucleotides and nucleosides play critical roles in various pathological conditions, including tumor cell growth. Adenosine triphosphate (ATP) activates pro-tumor receptors, while adenosine (ADO) is a potent immunosuppressant and modulator of cell growth. This study aims to analyze the purinergic actions of ATP and its metabolites, associated enzymes, and P1 or P2 class receptors in primary central nervous system tumors. Additionally, we sought to correlate the levels of nucleosides and the density of P1, P2X, and P2Y receptors in cells with tumor progression. The results indicate that purinergic signaling depends on the receptor concentration and signaling molecules specific to each cell type, tissue, and tumor histology. The purinergic system may function as either a tumor-promoting agent or an antitumor factor, depending on the microenvironmental conditions and the concentrations of receptors and their respective activators. Notably, ATP emerges as the most significant extracellular signal, capable of being converted into other cellular stimulators pertinent to neoplasms, such as adenosine diphosphate, adenosine monophosphate, adenosine, and inosine. Consequently, a cascade of responses to these stimuli promotes tumor development, cell division, and metastasis. Purine nucleotides in central nervous system tumors are pivotal in cellular responses in glioblastoma multiforme, vestibular schwannoma, medulloblastoma, adenomas, gliomas, meningiomas, and pineal tumors. These findings hold the potential for developing novel therapeutic strategies and aiding in therapeutic management.</p>","PeriodicalId":20952,"journal":{"name":"Purinergic Signalling","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Purines and purinergic receptors in primary tumors of the central nervous system.\",\"authors\":\"Adinei Abadio Soares, Helamã Moraes Dos Santos, Keyllor Nunes Domann, Natália Pratis Rocha Alves, Bernardo Ribeiro Böhm, Carolina Maliska Haack, Kailane Paula Pretto, Emily Sanini Guimarães, Guilherme Francisquini Rocha, Igor Rodrigues de Paula, Lucas Efraim de Alcântara Guimarães, Harlan Cleyton de Ávila Pessoa, Robison David Rodrigues, Angela Makeli Kososki Dalagnol, Marcelo Lemos Vieira da Cunha, Débora Tavares de Resende E Silva\",\"doi\":\"10.1007/s11302-024-10053-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Purine nucleotides and nucleosides play critical roles in various pathological conditions, including tumor cell growth. Adenosine triphosphate (ATP) activates pro-tumor receptors, while adenosine (ADO) is a potent immunosuppressant and modulator of cell growth. This study aims to analyze the purinergic actions of ATP and its metabolites, associated enzymes, and P1 or P2 class receptors in primary central nervous system tumors. Additionally, we sought to correlate the levels of nucleosides and the density of P1, P2X, and P2Y receptors in cells with tumor progression. The results indicate that purinergic signaling depends on the receptor concentration and signaling molecules specific to each cell type, tissue, and tumor histology. The purinergic system may function as either a tumor-promoting agent or an antitumor factor, depending on the microenvironmental conditions and the concentrations of receptors and their respective activators. Notably, ATP emerges as the most significant extracellular signal, capable of being converted into other cellular stimulators pertinent to neoplasms, such as adenosine diphosphate, adenosine monophosphate, adenosine, and inosine. Consequently, a cascade of responses to these stimuli promotes tumor development, cell division, and metastasis. Purine nucleotides in central nervous system tumors are pivotal in cellular responses in glioblastoma multiforme, vestibular schwannoma, medulloblastoma, adenomas, gliomas, meningiomas, and pineal tumors. 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Purines and purinergic receptors in primary tumors of the central nervous system.
Purine nucleotides and nucleosides play critical roles in various pathological conditions, including tumor cell growth. Adenosine triphosphate (ATP) activates pro-tumor receptors, while adenosine (ADO) is a potent immunosuppressant and modulator of cell growth. This study aims to analyze the purinergic actions of ATP and its metabolites, associated enzymes, and P1 or P2 class receptors in primary central nervous system tumors. Additionally, we sought to correlate the levels of nucleosides and the density of P1, P2X, and P2Y receptors in cells with tumor progression. The results indicate that purinergic signaling depends on the receptor concentration and signaling molecules specific to each cell type, tissue, and tumor histology. The purinergic system may function as either a tumor-promoting agent or an antitumor factor, depending on the microenvironmental conditions and the concentrations of receptors and their respective activators. Notably, ATP emerges as the most significant extracellular signal, capable of being converted into other cellular stimulators pertinent to neoplasms, such as adenosine diphosphate, adenosine monophosphate, adenosine, and inosine. Consequently, a cascade of responses to these stimuli promotes tumor development, cell division, and metastasis. Purine nucleotides in central nervous system tumors are pivotal in cellular responses in glioblastoma multiforme, vestibular schwannoma, medulloblastoma, adenomas, gliomas, meningiomas, and pineal tumors. These findings hold the potential for developing novel therapeutic strategies and aiding in therapeutic management.
期刊介绍:
Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.