中枢神经系统原发性肿瘤中的嘌呤和嘌呤能受体。

IF 3 4区 医学 Q2 NEUROSCIENCES
Adinei Abadio Soares, Helamã Moraes Dos Santos, Keyllor Nunes Domann, Natália Pratis Rocha Alves, Bernardo Ribeiro Böhm, Carolina Maliska Haack, Kailane Paula Pretto, Emily Sanini Guimarães, Guilherme Francisquini Rocha, Igor Rodrigues de Paula, Lucas Efraim de Alcântara Guimarães, Harlan Cleyton de Ávila Pessoa, Robison David Rodrigues, Angela Makeli Kososki Dalagnol, Marcelo Lemos Vieira da Cunha, Débora Tavares de Resende E Silva
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引用次数: 0

摘要

嘌呤核苷酸和核苷酸在包括肿瘤细胞生长在内的各种病理情况中发挥着关键作用。三磷酸腺苷(ATP)可激活促肿瘤受体,而腺苷(ADO)则是一种强效的免疫抑制剂和细胞生长调节剂。本研究旨在分析原发性中枢神经系统肿瘤中 ATP 及其代谢产物、相关酶、P1 或 P2 类受体的嘌呤能作用。此外,我们还试图将核苷的水平以及细胞中 P1、P2X 和 P2Y 受体的密度与肿瘤的进展联系起来。研究结果表明,嘌呤能信号传导取决于受体浓度以及每种细胞类型、组织和肿瘤组织学所特有的信号分子。嘌呤能系统可作为肿瘤促进剂或抗肿瘤因子发挥作用,这取决于微环境条件和受体及其各自激活剂的浓度。值得注意的是,ATP 是最重要的细胞外信号,可转化为与肿瘤有关的其他细胞刺激物,如二磷酸腺苷、单磷酸腺苷、腺苷和肌苷。因此,对这些刺激的一连串反应促进了肿瘤的发展、细胞分裂和转移。中枢神经系统肿瘤中的嘌呤核苷酸在多形性胶质母细胞瘤、前庭分裂瘤、髓母细胞瘤、腺瘤、胶质瘤、脑膜瘤和松果体瘤的细胞反应中起着关键作用。这些发现为开发新型治疗策略和辅助治疗管理提供了可能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Purines and purinergic receptors in primary tumors of the central nervous system.

Purine nucleotides and nucleosides play critical roles in various pathological conditions, including tumor cell growth. Adenosine triphosphate (ATP) activates pro-tumor receptors, while adenosine (ADO) is a potent immunosuppressant and modulator of cell growth. This study aims to analyze the purinergic actions of ATP and its metabolites, associated enzymes, and P1 or P2 class receptors in primary central nervous system tumors. Additionally, we sought to correlate the levels of nucleosides and the density of P1, P2X, and P2Y receptors in cells with tumor progression. The results indicate that purinergic signaling depends on the receptor concentration and signaling molecules specific to each cell type, tissue, and tumor histology. The purinergic system may function as either a tumor-promoting agent or an antitumor factor, depending on the microenvironmental conditions and the concentrations of receptors and their respective activators. Notably, ATP emerges as the most significant extracellular signal, capable of being converted into other cellular stimulators pertinent to neoplasms, such as adenosine diphosphate, adenosine monophosphate, adenosine, and inosine. Consequently, a cascade of responses to these stimuli promotes tumor development, cell division, and metastasis. Purine nucleotides in central nervous system tumors are pivotal in cellular responses in glioblastoma multiforme, vestibular schwannoma, medulloblastoma, adenomas, gliomas, meningiomas, and pineal tumors. These findings hold the potential for developing novel therapeutic strategies and aiding in therapeutic management.

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来源期刊
Purinergic Signalling
Purinergic Signalling 医学-神经科学
CiteScore
6.60
自引率
17.10%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.
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